2. Gene
  3. Pfkfb2 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Gene

Pfkfb2 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RH2K; PFK-2

Gene ID: 24640 | Gene type: protein coding

About Pfkfb2

Summary

Enables fructose-2,6-bisphosphate 2-phosphatase activity and kinase binding activity. Involved in several processes, including monocarboxylic acid metabolic process; positive regulation of Glucokinase activity; and positive regulation of Insulin secretion. Located in cytoplasm. Orthologous to human PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]

Pfkfb2 Products(3)

mRNA Protein Name
NM_001033964.2 NP_001029136.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform b
NM_001033965.2 NP_001029137.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform a
NM_080477.3 NP_536725.2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform c
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables fructose-2,6-bisphosphate 2-phosphatase activity IDA
IDA: Inferred from direct assay
18039179 RGD
enables kinase binding IPI
IPI: Inferred from physical interaction
11522786 RGD
Biological Process GO Annotation Evidence Reference Source
involved in glucose catabolic process IDA
IDA: Inferred from direct assay
16980436 RGD
involved in lactate metabolic process IDA
IDA: Inferred from direct assay
16980436 RGD
involved in positive regulation of glucokinase activity IDA
IDA: Inferred from direct assay
16980436 RGD
involved in positive regulation of insulin secretion IDA
IDA: Inferred from direct assay
16980436 RGD
involved in pyruvate metabolic process IDA
IDA: Inferred from direct assay
16980436 RGD
involved in response to glucose IDA
IDA: Inferred from direct assay
16980436 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (heart)

6PF-2-K/Fru-2,6-P2ASE heart-type isozyme

6PF-2-K/Fru-2,6-P2ase 2

PFK-2/FBPase-2

PFK/FBPase 2

fructose 6-phosphate 2-kinase/fructose 2,6-bisphosphatase

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101972 AZ-PFKFB3-67 Inhibitor 97.03% Unkown
HY-101971 AZ PFKFB3 26 Inhibitor 99.23% Unkown
HY-101972A AZ-PFKFB3-67 quarterhydrate Inhibitor ≥99.0% Unkown
HY-RS10362 PFKFB2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20188 Pfkfb2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26692 Pfkfb2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pfkfb2 NCBI NCBI:5208