Pfkfb1 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 Gene

Rattus norvegicus

Also known as PFRX; Pfkfb01

Gene ID: 24638 | Gene type: protein coding

About Pfkfb1

Summary

Enables several functions, including 6-phosphofructo-2-kinase activity; anion binding activity; and fructose-2,6-bisphosphate 2-phosphatase activity. Involved in several processes, including carbohydrate phosphorylation; positive regulation of Glucokinase activity; and response to peptide hormone. Part of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex. Biomarker of hyperinsulinism. Orthologous to human PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pfkfb1 Products(3)

mRNA	Protein	Name
NM_001271063.1	NP_001257992.1	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 2
NM_001271064.1	NP_001257993.1	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 3
NM_012621.4	NP_036753.4	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 6-phosphofructo-2-kinase activity	IDA IDA: Inferred from direct assay	7619077	RGD
enables ATP binding	IDA IDA: Inferred from direct assay	7619077	RGD
enables fructose-2,6-bisphosphate 2-phosphatase activity	IDA IDA: Inferred from direct assay	7619077	RGD
enables fructose-6-phosphate binding	IDA IDA: Inferred from direct assay	7619077	RGD
enables identical protein binding	IDA IDA: Inferred from direct assay	7619077	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	8634242	RGD
enables kinase binding	IPI IPI: Inferred from physical interaction	11522786	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	1315037	RGD
involved in carbohydrate phosphorylation	IDA IDA: Inferred from direct assay	7619077	RGD
involved in positive regulation of glucokinase activity	IMP IMP: Inferred from mutant phenotype	15047617	RGD
involved in positive regulation of glycolytic process through fructose-6-phosphate	IMP IMP: Inferred from mutant phenotype	12230553	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	7593243	RGD
involved in response to glucagon	IEP IEP: Inferred from expression pattern	7593243	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	7593243	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	8131849	RGD
involved in response to starvation	IEP IEP: Inferred from expression pattern	9705027	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex	IDA IDA: Inferred from direct assay	7619077	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

6-PF2-K/Fru-2,6-P2ase	6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase
6PF-2-K/Fru-2,6-P2ASE liver isozyme	6PF-2-K/Fru-2,6-P2ase 1
PFK/FBPase 1	PFK2/FBPase2

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101972	AZ-PFKFB3-67	Inhibitor	97.03%	Unkown
HY-101971	AZ PFKFB3 26	Inhibitor	99.23%	Unkown
HY-101972A	AZ-PFKFB3-67 quarterhydrate	Inhibitor	≥99.0%	Unkown
HY-RS10361	PFKFB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20187	Pfkfb1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26691	Pfkfb1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pfkfb1	NCBI	NCBI:5207

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