Grin2a - glutamate ionotropic receptor NMDA type subunit 2A Gene

Rattus norvegicus

Also known as NR2A; GluN2A; NMDAR2A

Gene ID: 24409 | Gene type: protein coding

About Grin2a

Summary

Enables several functions, including enzyme binding activity; glutamate binding activity; and ligand-gated ion channel activity. Contributes to cation channel activity and extracellularly glutamate-gated ion channel activity. Involved in several processes, including cellular response to metal ion; central nervous system development; and modulation of chemical synaptic transmission. Located in several cellular components, including dendritic spine; postsynaptic density; and synaptic membrane. Is integral component of plasma membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse and parallel fiber to Purkinje cell synapse. Is integral component of presynaptic membrane. Used to study hyperhomocysteinemia. Biomarker of cognitive disorder; placental insufficiency; and status epilepticus. Human ortholog(s) of this gene implicated in Huntington's disease; bipolar disorder; and schizophrenia. Orthologous to human GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A). [provided by Alliance of Genome Resources, Apr 2022]

Grin2a Products(1)

mRNA	Protein	Name
NM_012573.4	NP_036705.3	glutamate receptor ionotropic, NMDA 2A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	19406213	RGD
enables NMDA glutamate receptor activity	IDA IDA: Inferred from direct assay	8428958	RGD
enables NMDA glutamate receptor activity	IMP IMP: Inferred from mutant phenotype	17050728	RGD
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	34233182	RGD
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	16540568	RGD
contributes to extracellularly glutamate-gated ion channel activity	IMP IMP: Inferred from mutant phenotype	9425000	RGD
enables glutamate binding	IDA IDA: Inferred from direct assay	22098737	RGD
enables glutamate binding	IMP IMP: Inferred from mutant phenotype	9425000	RGD
enables glutamate receptor binding	IPI IPI: Inferred from physical interaction	11239437	RGD
enables glutamate-gated receptor activity	IDA IDA: Inferred from direct assay	16477151	RGD
contributes to glutamate-gated receptor activity	IMP IMP: Inferred from mutant phenotype	19154422	RGD
enables glutamate-gated receptor activity	IMP IMP: Inferred from mutant phenotype	19240037	RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	EXP EXP: Inferred from Experiment	19666514	RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA IDA: Inferred from direct assay	19666514	RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	19666514	RGD
contributes to monoatomic cation channel activity	IDA IDA: Inferred from direct assay	12408866	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	7569905	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	11478920	RGD
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	11239437	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	21544205	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	12618293	RGD
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	20847060	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	12408866	RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	12160751	RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	12160751	RGD
enables voltage-gated monoatomic cation channel activity	IMP IMP: Inferred from mutant phenotype	17050728	RGD
enables zinc ion binding	IDA IDA: Inferred from direct assay	19240037	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in action potential	IMP IMP: Inferred from mutant phenotype	16904707	RGD
involved in auditory behavior	IEP IEP: Inferred from expression pattern	30137254	RGD
involved in cellular response to amino acid stimulus	IMP IMP: Inferred from mutant phenotype	19154422	RGD
involved in cellular response to dsRNA	IEP IEP: Inferred from expression pattern	19958814	RGD
involved in cellular response to glycine	IEP IEP: Inferred from expression pattern	23678131	RGD
involved in cellular response to growth factor stimulus	IEP IEP: Inferred from expression pattern	19958814	RGD
involved in cellular response to lipid	IEP IEP: Inferred from expression pattern	19819306	RGD
involved in cellular response to magnesium ion	IEP IEP: Inferred from expression pattern	19154422	RGD
involved in cellular response to manganese ion	IEP IEP: Inferred from expression pattern	19643132	RGD
involved in cellular response to zinc ion	IMP IMP: Inferred from mutant phenotype	19240037	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	19409459	RGD
involved in chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	15306812	RGD
involved in conditioned place preference	IEP IEP: Inferred from expression pattern	23506787	RGD
involved in dendritic spine organization	IMP IMP: Inferred from mutant phenotype	26679993	RGD
involved in excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	20164351	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	19535712	RGD
involved in ionotropic glutamate receptor signaling pathway	IDA IDA: Inferred from direct assay	16477151	RGD
involved in long-term synaptic potentiation	IEP IEP: Inferred from expression pattern	26088419	RGD
involved in memory	IDA IDA: Inferred from direct assay	16157280	RGD
involved in modulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	34233182	RGD
involved in monoatomic cation transmembrane transport	IDA IDA: Inferred from direct assay	22246434	RGD
involved in multicellular organismal response to stress	IEP IEP: Inferred from expression pattern	26679226	RGD
involved in neuron development	IEP IEP: Inferred from expression pattern	16477151	RGD
involved in neurotransmitter receptor transport, plasma membrane to endosome	IMP IMP: Inferred from mutant phenotype	34233182	RGD
involved in positive regulation of excitatory postsynaptic potential	IDA IDA: Inferred from direct assay	12930820	RGD
involved in positive regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	29339324	RGD
involved in positive regulation of inhibitory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	29339324	RGD
involved in positive regulation of protein targeting to membrane	IMP IMP: Inferred from mutant phenotype	23678131	RGD
involved in positive regulation of synaptic transmission, glutamatergic	IDA IDA: Inferred from direct assay	19793963	RGD
involved in receptor recycling	IMP IMP: Inferred from mutant phenotype	34233182	RGD
involved in regulation of ARF protein signal transduction	IGI IGI: Inferred from genetic interaction	26884337	RGD
involved in regulation of NMDA receptor activity	IMP IMP: Inferred from mutant phenotype	26679993	RGD
involved in regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	16904707	RGD
involved in regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	30544257	RGD
involved in regulation of monoatomic cation transmembrane transport	IDA IDA: Inferred from direct assay	22246434	RGD
involved in regulation of response to alcohol	IEP IEP: Inferred from expression pattern	23506787	RGD
involved in response to amine	IEP IEP: Inferred from expression pattern	19918184	RGD
involved in response to ammonium ion	IEP IEP: Inferred from expression pattern	20084674	RGD
involved in response to calcium ion	IEP IEP: Inferred from expression pattern	19761817	RGD
involved in response to carbohydrate	IEP IEP: Inferred from expression pattern	19695778	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	19322657	RGD
involved in response to environmental enrichment	IEP IEP: Inferred from expression pattern	26679226	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	19673743	RGD
involved in response to ethanol	IMP IMP: Inferred from mutant phenotype	27876530	RGD
involved in response to fungicide	IEP IEP: Inferred from expression pattern	19591855	RGD
involved in response to hydrogen sulfide	IEP IEP: Inferred from expression pattern	23242725	RGD
involved in response to lead ion	IEP IEP: Inferred from expression pattern	30137254	RGD
involved in response to light stimulus	IEP IEP: Inferred from expression pattern	19850826	RGD
involved in response to lithium ion	IDA IDA: Inferred from direct assay	12932824	RGD
involved in response to manganese ion	IEP IEP: Inferred from expression pattern	20175136	RGD
involved in response to methylmercury	IEP IEP: Inferred from expression pattern	19409459	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	16040357	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	19322657	RGD
involved in response to other organism	IEP IEP: Inferred from expression pattern	19563853	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	20084674	RGD
involved in rhythmic process	IDA IDA: Inferred from direct assay	16477151	RGD
involved in spinal cord development	IEP IEP: Inferred from expression pattern	19446017	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of NMDA selective glutamate receptor complex	IDA IDA: Inferred from direct assay	8702950	RGD
located in cell surface	IDA IDA: Inferred from direct assay	26088419	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	16477151	RGD
located in dendrite membrane	IDA IDA: Inferred from direct assay	23678131	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	16221859	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	19666514	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	12160751	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	12160751	RGD
located in neuron projection	IDA IDA: Inferred from direct assay	12738960	RGD
is active in parallel fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	19666514	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	23625947	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	9509416	RGD
located in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	26088419	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	9509416	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	19666514	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	16157280	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	19666514	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glutamate receptor ionotropic, NMDA 2A

N-methyl D-aspartate receptor subtype 2A	N-methyl-D-aspartate receptor subunit 2A
glutamate [NMDA] receptor subunit epsilon-1	glutamate receptor, ionotropic, N-methyl D-aspartate 2A

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05804	GRIN2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21136	Grin2a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27654	Grin2a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grin2a	NCBI	NCBI:2903

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