2. Gene
  3. Cyp11b2 - cytochrome P450, family 11, subfamily b, polypeptide 2 Gene

Cyp11b2 - cytochrome P450, family 11, subfamily b, polypeptide 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as ALDOS; Cp45as; Cyp11b3; RNCP45AS

Gene ID: 24294 | Gene type: protein coding

About Cyp11b2

Summary

Enables corticosterone 18-monooxygenase activity and steroid 11-beta-monooxygenase activity. Involved in several processes, including cellular response to nutrient levels; response to peptide hormone; and steroid biosynthetic process. Located in dendrite. Used to study heart disease; hypertension; and myocardial infarction. Biomarker of congestive heart failure; hypertension; myocarditis; and renal tubular acidosis. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to several human genes including CYP11B1 (Cytochrome P450 family 11 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp11b2 Products(1)

mRNA Protein Name
NM_012538.2 NP_036670.2 cytochrome P450 11B2, mitochondrial
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables corticosterone 18-monooxygenase activity IDA
IDA: Inferred from direct assay
2350348 RGD
enables steroid 11-beta-monooxygenase activity IDA
IDA: Inferred from direct assay
8333830 RGD
Biological Process GO Annotation Evidence Reference Source
involved in C21-steroid hormone biosynthetic process IDA
IDA: Inferred from direct assay
11832364 RGD
involved in aldosterone biosynthetic process IDA
IDA: Inferred from direct assay
11832364 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
19478813 RGD
involved in cellular response to nutrient IEP
IEP: Inferred from expression pattern
16876110 RGD
involved in cellular response to peptide hormone stimulus IEP
IEP: Inferred from expression pattern
20685870 RGD
involved in cellular response to potassium ion starvation IEP
IEP: Inferred from expression pattern
20685870 RGD
involved in glucocorticoid biosynthetic process IDA
IDA: Inferred from direct assay
11832364 RGD
involved in positive regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
18495825 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
16043663 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
16882930 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
18252953 RGD
involved in response to salt stress IEP
IEP: Inferred from expression pattern
19118098 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16043663 RGD
Cellular Component GO Annotation Evidence Reference Source
located in dendrite IDA
IDA: Inferred from direct assay
12459034 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytochrome P450 11B2, mitochondrial

CYPXIB2

CYPXIB3

Cytochrome P450, subfamily XIB, polypeptide 2 (aldosterone synthase)

P450-Aldo-1

P450-Aldo-2

aldosterone synthase

aldosterone-synthesizing enzyme

corticosterone 18-monooxygenase, CYP11B2

cytochrome P-450Aldo

cytochrome P-450C18

c

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16276 Osilodrostat Inhibitor 99.90% Yes
HY-16276A Osilodrostat phosphate Inhibitor 99.35% Yes
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-19833 CFG920 Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-113151 18-Oxocortisol Antagonist 99.86% Unkown
HY-155493 CYP19A1/CYP11B2-IN-1 Inhibitor 99.85% Unkown
HY-101217 BI 689648 Inhibitor 99.20% Unkown
HY-135281 CYP11B2-IN-1 Inhibitor 99.83% Unkown
HY-RS03436 CYP11B2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-162574 CYP11B2-IN-2 Inhibitor / Unkown
HY-163751 STING-IN-9 Inhibitor / Unkown
HY-RS17177 Cyp11b2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23627 Cyp11b2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W002108 3,4-Dihydroquinolin-2(1H)-one ≥95.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyp11b2 NCBI NCBI:1585