Chrm3 - cholinergic receptor, muscarinic 3 Gene

Rattus norvegicus

Gene ID: 24260 | Gene type: protein coding

About Chrm3

Summary

Enables several functions, including G protein-coupled acetylcholine receptor activity; G protein-coupled acetylcholine receptor binding activity; and acetylcholine binding activity. Involved in G protein-coupled acetylcholine receptor signaling pathway; negative regulation of heart rate by acetylcholine; and positive regulation of vascular associated smooth muscle contraction. Located in several cellular components, including asymmetric synapse; axon terminus; and dendrite. Is integral component of plasma membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in bladder disease; chronic obstructive pulmonary disease; prune belly syndrome; and pulmonary fibrosis. Orthologous to human CHRM3 (cholinergic receptor muscarinic 3). [provided by Alliance of Genome Resources, Apr 2022]

Chrm3 Products(1)

mRNA	Protein	Name
NM_012527.2	NP_036659.2	muscarinic acetylcholine receptor M3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled acetylcholine receptor activity	IDA IDA: Inferred from direct assay	1527051	RGD
enables G protein-coupled acetylcholine receptor binding	IDA IDA: Inferred from direct assay	9316844	RGD
enables acetylcholine binding	IDA IDA: Inferred from direct assay	1527051	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	20461055	RGD
enables quaternary ammonium group binding	IDA IDA: Inferred from direct assay	8075871	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled acetylcholine receptor signaling pathway	IDA IDA: Inferred from direct assay	1527051	RGD
involved in G protein-coupled acetylcholine receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15141107	RGD
involved in negative regulation of heart rate by acetylcholine	IMP IMP: Inferred from mutant phenotype	9316844	RGD
involved in positive regulation of vascular associated smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	8428203	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	9316844	RGD
involved in response to acetylcholine	IMP IMP: Inferred from mutant phenotype	8075871	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in asymmetric synapse	IDA IDA: Inferred from direct assay	8182478	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	8182478	RGD
located in dendrite	IDA IDA: Inferred from direct assay	8182478	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	8182478	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	1527051	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	8182478	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	8182478	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

muscarinic acetylcholine receptor M3

cholinergic receptor, muscarinic 3, cardiac

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02662	CHRM3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19180	Chrm3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25668	Chrm3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Chrm3	NCBI	NCBI:1131

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