Atp1a1 - ATPase Na+/K+ transporting subunit alpha 1 Gene

Rattus norvegicus

Also known as Nkaa1b

Gene ID: 24211 | Gene type: protein coding

About Atp1a1

Summary

Enables several functions, including adenyl ribonucleotide binding activity; alkali metal ion binding activity; and ankyrin binding activity. Involved in several processes, including cellular response to mechanical stimulus; inorganic cation transmembrane transport; and membrane hyperpolarization. Located in several cellular components, including T-tubule; basolateral plasma membrane; and intercalated disc. Part of sodium:potassium-exchanging ATPase complex. Used to study hypertension. Biomarker of hyperhomocysteinemia and sensorineural hearing loss. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2DD. Orthologous to human ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

Atp1a1 Products(1)

mRNA	Protein	Name
NM_012504.1	NP_036636.1	sodium/potassium-transporting ATPase subunit alpha-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ADP binding	IDA IDA: Inferred from direct assay	12730684	RGD
enables ATP binding	IDA IDA: Inferred from direct assay	12730684	RGD
enables P-type sodium:potassium-exchanging transporter activity	IDA IDA: Inferred from direct assay	12531906	RGD
enables ankyrin binding	IPI IPI: Inferred from physical interaction	8159688	RGD
enables phosphatidylinositol 3-kinase binding	IPI IPI: Inferred from physical interaction	17728397	RGD
enables potassium ion binding	IDA IDA: Inferred from direct assay	16269407	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12093728	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	16269407	RGD
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	28787093	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17939993	RGD
enables protein-folding chaperone binding	IDA IDA: Inferred from direct assay	18768923	RGD
enables sodium ion binding	IDA IDA: Inferred from direct assay	16269407	RGD
enables sodium ion binding	IMP IMP: Inferred from mutant phenotype	18075585	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to mechanical stimulus	IDA IDA: Inferred from direct assay	17458903	RGD
involved in membrane hyperpolarization	IMP IMP: Inferred from mutant phenotype	17001300	RGD
involved in potassium ion import across plasma membrane	IDA IDA: Inferred from direct assay	12531906	RGD
involved in potassium ion transport	IDA IDA: Inferred from direct assay	12093728	RGD
involved in regulation of cardiac muscle cell contraction	IMP IMP: Inferred from mutant phenotype	15629895	RGD
involved in regulation of sodium ion transport	IDA IDA: Inferred from direct assay	17939993	RGD
involved in sodium ion export across plasma membrane	IDA IDA: Inferred from direct assay	18075585	RGD
involved in sodium ion transport	IDA IDA: Inferred from direct assay	12093728	RGD
involved in transmembrane transport	IDA IDA: Inferred from direct assay	18075585	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	18768923	RGD
located in T-tubule	IDA IDA: Inferred from direct assay	17442282	RGD
located in basolateral plasma membrane	IMP IMP: Inferred from mutant phenotype	16914892	RGD
located in caveola	IDA IDA: Inferred from direct assay	16624992	RGD
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	18768923	RGD
located in endosome	IDA IDA: Inferred from direct assay	16893515	RGD
located in intercalated disc	IDA IDA: Inferred from direct assay	17442282	RGD
located in membrane	IDA IDA: Inferred from direct assay	28787093	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	18768923	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	17442282	RGD
part of sodium:potassium-exchanging ATPase complex	IDA IDA: Inferred from direct assay	12093728	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sodium/potassium-transporting ATPase subunit alpha-1

ATPase, Na+/K+ transporting, alpha 1 polypeptide	ATPase, Na+K+ transporting, alpha 1
Na(+)/K(+) ATPase alpha-1 subunit	sodium pump subunit alpha-1

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12283	Rostafuroxin		99.03%	Phase 2

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2657	Verucopeptin	Inhibitor	≥99.0%	Unkown
HY-P1565A	Transdermal Peptide Disulfide TFA	Inhibitor	98.86%	Unkown
HY-RS01182	ATP1A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-P1565	Transdermal Peptide Disulfide	Inhibitor	/	Unkown
HY-RS01186	ATP1B1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16918	Atp1a1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21097	Atp1b1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23361	Atp1a1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27615	Atp1b1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atp1a1	NCBI	NCBI:476

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