Apoc3 - apolipoprotein C3 Gene

Rattus norvegicus

Also known as ApoC-III; apo-CIII

Gene ID: 24207 | Gene type: protein coding

About Apoc3

Summary

Predicted to enable high-density lipoprotein particle receptor binding activity; Lipase Inhibitor activity; and phospholipid binding activity. Involved in several processes, including lipoprotein transport; negative regulation of oxidative phosphorylation; and positive regulation of triglyceride biosynthetic process. Located in extracellular space. Used to study hyperthyroidism; hypothyroidism; and type 1 diabetes mellitus. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in several diseases, including Apolipoprotein C-III deficiency; chronic kidney disease; coronary artery disease; familial hyperlipidemia (multiple); and glucose metabolism disease (multiple). Orthologous to human apoC3 (Apolipoprotein C3). [provided by Alliance of Genome Resources, Apr 2022]

Apoc3 Products(2)

mRNA	Protein	Name
NM_001271053.1	NP_001257982.1	apolipoprotein C-III precursor
NM_012501.2	NP_036633.2	apolipoprotein C-III precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	21183731	RGD
involved in lipoprotein transport	IDA IDA: Inferred from direct assay	4020294	RGD
involved in negative regulation of oxidative phosphorylation	IDA IDA: Inferred from direct assay	11177239	RGD
involved in positive regulation of triglyceride biosynthetic process	IMP IMP: Inferred from mutant phenotype	23542898	RGD
involved in response to fatty acid	IEP IEP: Inferred from expression pattern	20938723	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	7811230	RGD
involved in response to peptide hormone	IDA IDA: Inferred from direct assay	8429259	RGD
involved in response to triglyceride	IEP IEP: Inferred from expression pattern	6698975	RGD
involved in response to vitamin A	IEP IEP: Inferred from expression pattern	7811230	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	9888873	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	6419747	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

apolipoprotein C-III

apolipoprotein C-3

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145727	Volanesorsen	Inhibitor	97.97%	Unkown
HY-145727A	Volanesorsen sodium	Inhibitor	98.51%	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-164740A	Plozasiran sodium	Inhibitor	96.87%	Phase 3
HY-153491A	Olezarsen sodium	Inhibitor	91.44%	Phase 3
HY-153491	Olezarsen	Inhibitor	/	Phase 3
HY-164740	Plozasiran	Inhibitor	96.87%	Phase 3

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00846	APOC3 Human Pre-designed siRNA Set A	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Apoc3	NCBI	NCBI:345
Mus musculus	Apoc3	NCBI	NCBI:11814

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