Akr1b1 - aldo-keto reductase family 1 member B1 Gene

Rattus norvegicus

Also known as Alr; Aldr1; ALDRED; Akr1b3; Akr1b4; ALR-P-I; RATALDRED

Gene ID: 24192 | Gene type: protein coding

About Akr1b1

Summary

Enables alditol:NADP+ 1-oxidoreductase activity and cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity. Involved in several processes, including inner medullary collecting duct development; positive regulation of receptor signaling pathway via JAK-STAT; and sorbitol biosynthetic process. Located in several cellular components, including Schmidt-Lanterman incisure; Schwann cell microvillus; and mast cell granule. Used to study allergic disease; cataract; diabetic neuropathy; and diabetic retinopathy. Biomarker of diabetic retinopathy; galactosemia; hepatocellular carcinoma; hyperglycemia; and hypokalemia. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B). [provided by Alliance of Genome Resources, Apr 2022]

Akr1b1 Products(1)

mRNA	Protein	Name
NM_012498.1	NP_036630.1	aldo-keto reductase family 1 member B1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables aldose reductase (NADPH) activity	IDA IDA: Inferred from direct assay	2114645	RGD
enables cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity	IDA IDA: Inferred from direct assay	8407226	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to methylglyoxal	IDA IDA: Inferred from direct assay	12604218	RGD
involved in cellular response to peptide	IEP IEP: Inferred from expression pattern	17490626	RGD
involved in inner medullary collecting duct development	IDA IDA: Inferred from direct assay	1401064	RGD
involved in maternal process involved in female pregnancy	IEP IEP: Inferred from expression pattern	2121099	RGD
involved in monosaccharide metabolic process	IDA IDA: Inferred from direct assay	2119895	RGD
involved in norepinephrine metabolic process	IDA IDA: Inferred from direct assay	10424772	RGD
involved in positive regulation of receptor signaling pathway via JAK-STAT	IMP IMP: Inferred from mutant phenotype	15746188	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	16648138	RGD
involved in response to thyroid hormone	IEP IEP: Inferred from expression pattern	19422879	RGD
involved in sorbitol biosynthetic process	IMP IMP: Inferred from mutant phenotype	6690344	RGD
involved in stress-activated protein kinase signaling cascade	IMP IMP: Inferred from mutant phenotype	16669970	RGD
involved in tissue homeostasis	IMP IMP: Inferred from mutant phenotype	21376710	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Schmidt-Lanterman incisure	IDA IDA: Inferred from direct assay	1650113	RGD
located in Schwann cell microvillus	IDA IDA: Inferred from direct assay	1650113	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	16332428	RGD
located in mast cell granule	IDA IDA: Inferred from direct assay	1650113	RGD
located in paranodal junction	IDA IDA: Inferred from direct assay	1650113	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	8150024	RGD
located in plasma membrane bounded cell projection cytoplasm	IDA IDA: Inferred from direct assay	8150024	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

aldo-keto reductase family 1 member B1

AR	Aldehyde reductase 1 (low Km aldose reductase) (5.8 kb PstI fragment, probably the functional gene)
aldo-keto reductase family 1 member B	aldose reductase

Akr1b1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85558	Aldose Reductase Antibody (YA5250)	WB	Human, Mouse, Rat

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-106697	Ponalrestat	Inhibitor	99.51%	Phase 3

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0310	Soyasaponin Bb		99.75%	Unkown
HY-133708	β-Glucogallin		99.82%	Unkown
HY-149254	PTP1B/AKR1B1-IN-1	Inhibitor	/	Unkown
HY-149255	PTP1B/AKR1B1-IN-2	Inhibitor	/	Unkown
HY-176719	AKR1B1/STAT3/SLC7A11-regulator-1		/	Unkown
HY-RS00532	AKR1B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17235	Akr1b1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23688	Akr1b1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Akr1b1	NCBI	NCBI:231

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