Adrb2 - adrenoceptor beta 2 Gene

Rattus norvegicus

Gene ID: 24176 | Gene type: protein coding

About Adrb2

Summary

Enables several functions, including G-protein alpha-subunit binding activity; beta2-adrenergic receptor activity; and signaling receptor binding activity. Involved in several processes, including chemical synaptic transmission; positive regulation of ion transport; and response to steroid hormone. Located in several cellular components, including caveola; neuronal cell body membrane; and sarcolemma. Is active in glutamatergic synapse. Used to study cardiomyopathy (multiple); congestive heart failure; kidney disease (multiple); and lung disease (multiple). Biomarker of several diseases, including acute kidney failure; artery disease (multiple); congestive heart failure; polycystic ovary syndrome; and ulcerative colitis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); disease of metabolism (multiple); kidney failure (multiple); lung disease (multiple); and open-angle glaucoma (multiple). Orthologous to human ADRB2 (adrenoceptor beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Adrb2 Products(1)

mRNA	Protein	Name
NM_012492.2	NP_036624.2	beta-2 adrenergic receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables B2 bradykinin receptor binding	IPI IPI: Inferred from physical interaction	20150590	RGD
enables G-protein alpha-subunit binding	IPI IPI: Inferred from physical interaction	19942860	RGD
enables beta2-adrenergic receptor activity	IDA IDA: Inferred from direct assay	6247002	RGD
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	19942860	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11441182	RGD
enables protein phosphatase 2A binding	IPI IPI: Inferred from physical interaction	20395454	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	15141163	RGD
enables receptor-receptor interaction	IPI IPI: Inferred from physical interaction	20395454	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	12514203	RGD
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	2153813	RGD
involved in associative learning	IDA IDA: Inferred from direct assay	2573754	RGD
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	19098126	RGD
involved in diaphragm contraction	IDA IDA: Inferred from direct assay	17362795	RGD
involved in estrous cycle	IEP IEP: Inferred from expression pattern	7977723	RGD
involved in excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	17175110	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	7977723	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	8408243	RGD
involved in liver regeneration	IEP IEP: Inferred from expression pattern	8855951	RGD
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	22495178	RGD
involved in negative regulation of ossification	IMP IMP: Inferred from mutant phenotype	16177600	RGD
involved in negative regulation of urine volume	IMP IMP: Inferred from mutant phenotype	7912752	RGD
involved in positive regulation of ATP-dependent activity	IMP IMP: Inferred from mutant phenotype	8760245	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15591297	RGD
involved in positive regulation of calcium ion import across plasma membrane	IDA IDA: Inferred from direct assay	11408541	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	16005083	RGD
involved in positive regulation of potassium ion transport	IDA IDA: Inferred from direct assay	6247002	RGD
involved in positive regulation of skeletal muscle tissue growth	IMP IMP: Inferred from mutant phenotype	16177600	RGD
involved in positive regulation of sodium ion transport	IDA IDA: Inferred from direct assay	6247002	RGD
involved in positive regulation of the force of heart contraction by epinephrine	IDA IDA: Inferred from direct assay	19133992	RGD
involved in presynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	17175110	RGD
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	17175110	RGD
involved in regulation of calcium ion transport	IDA IDA: Inferred from direct assay	12514203	RGD
involved in response to catecholamine	IDA IDA: Inferred from direct assay	6381693	RGD
involved in response to dexamethasone	IEP IEP: Inferred from expression pattern	7588441	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	11431147	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	21562317	RGD
involved in response to monoamine	IEP IEP: Inferred from expression pattern	1664493	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	1314813	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	2845194	RGD
involved in synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	17175110	RGD
involved in vasodilation	IDA IDA: Inferred from direct assay	15351777	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	11441182	RGD
located in axon	IDA IDA: Inferred from direct assay	15682824	RGD
located in caveola	IDA IDA: Inferred from direct assay	15961389	RGD
located in dendrite	IDA IDA: Inferred from direct assay	15682824	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	11441182	RGD
located in endosome	IDA IDA: Inferred from direct assay	12932836	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	17175110	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17175110	RGD
located in neuronal cell body membrane	IDA IDA: Inferred from direct assay	11441182	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	11441182	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	15961389	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

beta-2 adrenergic receptor

Adrenergic beta 2- receptor surface	adrenergic receptor, beta 2
adrenergic, beta-2-, receptor, surface	adrenoceptor beta 2, surface
beta-2 adrenoceptor	beta-2 adrenoreceptor

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14299A	Indacaterol maleate	Agonist	99.82%	Unkown
HY-14299	Indacaterol	Agonist	99.98%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14299D	Indacaterol acetate	Agonist	/	Phase 4

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13338	Mabuterol	Agonist	99.96%	Unkown
HY-RS00415	ADRB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06458	HTR1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-14299B	(S)-Indacaterol		/	Unkown
HY-152051S	Mabuterol-d9 hydrochloride	Agonist	/	Unkown
HY-RS16956	Adrb2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23399	Adrb2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W755295	Mabuterol hydrochloride	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adrb2	NCBI	NCBI:154

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