Acadm - acyl-CoA dehydrogenase medium chain Gene

Rattus norvegicus

Also known as MCAD

Gene ID: 24158 | Gene type: protein coding

About Acadm

Summary

Enables several functions, including acyl-CoA dehydrogenase activity; identical protein binding activity; and nucleotide binding activity. Involved in several processes, including fatty acid catabolic process; response to copper ion; and response to glucocorticoid. Located in mitochondrial matrix and mitochondrial membrane. Biomarker of non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in medium chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADM (acyl-CoA dehydrogenase medium chain). [provided by Alliance of Genome Resources, Apr 2022]

Acadm Products(1)

mRNA	Protein	Name
NM_016986.2	NP_058682.2	medium-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables acyl-CoA dehydrogenase activity	IDA IDA: Inferred from direct assay	3968063	RGD
enables flavin adenine dinucleotide binding	IDA IDA: Inferred from direct assay	3968063	RGD
enables identical protein binding	IDA IDA: Inferred from direct assay	3813556	RGD
enables isomerase activity	IDA IDA: Inferred from direct assay	15850406	RGD
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	3968063	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase	IDA IDA: Inferred from direct assay	3968063	RGD
involved in medium-chain fatty acid catabolic process	IDA IDA: Inferred from direct assay	3968063	RGD
involved in response to copper ion	IEP IEP: Inferred from expression pattern	10958805	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	8615829	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	9164869	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	15863369	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	15852996	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	3813556	RGD
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	3813556	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

medium-chain specific acyl-CoA dehydrogenase, mitochondrial

Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight-chain	acyl-CoA dehydrogenase, C-4 to C-12 straight chain
acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain	acyl-Coenzyme A dehydrogenase, medium chain
medium-chain acyl-CoA dehydrogenase

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00128	ACADM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17544	Acadm Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24002	Acadm Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Acadm	NCBI	NCBI:34

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