Lrrc8a - leucine rich repeat containing 8A VRAC subunit A Gene

Mus musculus

Also known as ebo; Lrrc8; SWELL1; mKIAA1437

Gene ID: 241296 | Gene type: protein coding

About Lrrc8a

Summary

Predicted to enable cyclic-GMP-AMP transmembrane transporter activity; identical protein binding activity; and volume-sensitive anion channel activity. Predicted to contribute to anion channel activity. Predicted to be involved in several processes, including anion transport; cell volume homeostasis; and protein hexamerization. Predicted to act upstream of or within cell differentiation; ion transport; and spermatogenesis. Predicted to be located in cell surface and plasma membrane. Predicted to be integral component of lysosomal membrane and integral component of plasma membrane. Predicted to be part of ion channel complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; immune system; and nervous system. Human ortholog(s) of this gene implicated in agammaglobulinemia and agammaglobulinemia 5. Orthologous to human LRRC8A (leucine rich repeat containing 8 VRAC subunit A). [provided by Alliance of Genome Resources, Apr 2022]

Lrrc8a Products(1)

mRNA	Protein	Name
NM_177725.4	NP_808393.1	volume-regulated anion channel subunit LRRC8A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cyclic-GMP-AMP transmembrane transporter activity	IDA IDA: Inferred from direct assay	32277911	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	29769723	MGI
enables volume-sensitive anion channel activity	IDA IDA: Inferred from direct assay	29769723	MGI
enables volume-sensitive anion channel activity	IMP IMP: Inferred from mutant phenotype	29773801	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cyclic-GMP-AMP transmembrane import across plasma membrane	IDA IDA: Inferred from direct assay	32277911	MGI
involved in intracellular glucose homeostasis	IMP IMP: Inferred from mutant phenotype	29773801	MGI
involved in monoatomic anion transmembrane transport	IDA IDA: Inferred from direct assay	29769723	MGI
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	29773801	MGI
involved in positive regulation of myoblast differentiation	IMP IMP: Inferred from mutant phenotype	31387946	MGI
involved in pre-B cell differentiation	IMP IMP: Inferred from mutant phenotype	14660746	MGI
involved in protein hexamerization	IDA IDA: Inferred from direct assay	29769723	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	30135305	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of monoatomic ion channel complex	IDA IDA: Inferred from direct assay	29769723	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	29769723	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

volume-regulated anion channel subunit LRRC8A

leucine-rich repeat-containing 8	leucine-rich repeat-containing protein 8A
protein ebouriffe

Lrrc8a Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Lrrc8a	Q80WG5	Lrrc8a	Mus musculus	Q80WG5	3D-EM	30775971
Intra	Lrrc8a	Q80WG5	Lrrc8a	Mus musculus	Q80WG5	GMS	29769723
Intra	Lrrc8a	Q80WG5	Lrrc8a	Mus musculus	Q80WG5	SLS	29769723
Intra	Lrrc8a	Q80WG5	Lrrc8a	Mus musculus	Q80WG5	3D-EM	29769723
Intra	Lrrc8a	Q80WG5	Lrrc8c	Mus musculus	Q8R502	3D-EM	29769723

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07827	LRRC8A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21148	Lrrc8a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27665	Lrrc8a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lrrc8a	NCBI	NCBI:56262

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