Pacsin2 - protein kinase C and casein kinase substrate in neurons 2 Gene

Mus musculus

Also known as SdpII

Gene ID: 23970 | Gene type: protein coding

About Pacsin2

Summary

Enables cytoskeletal protein binding activity and lipid binding activity. Involved in cell projection morphogenesis; modulation of chemical synaptic transmission; and plasma membrane tubulation. Acts upstream of or within negative regulation of endocytosis. Located in caveola; cell-cell junction; and cytosol. Is extrinsic component of membrane. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; aorta; eye; genitourinary system; and thymus. Orthologous to human PACSIN2 (protein kinase C and Casein Kinase substrate in neurons 2). [provided by Alliance of Genome Resources, Apr 2022]

Pacsin2 Products(10)

mRNA	Protein	Name
NM_001159509.2	NP_001152981.1	protein kinase C and casein kinase substrate in neurons protein 2 isoform 1
NM_001159510.2	NP_001152982.1	protein kinase C and casein kinase substrate in neurons protein 2 isoform 1
NM_001358641.2	NP_001345570.1	protein kinase C and casein kinase substrate in neurons protein 2 isoform 2
NM_001358642.2	NP_001345571.1	protein kinase C and casein kinase substrate in neurons protein 2 isoform 3
NM_001358643.2	NP_001345572.1	protein kinase C and casein kinase substrate in neurons protein 2 isoform 4
NM_001358644.2	NP_001345573.1	protein kinase C and casein kinase substrate in neurons protein 2 isoform 3
NM_001411850.1	NP_001398779.1	protein kinase C and casein kinase substrate in neurons protein 2 isoform 1
NM_001411851.1	NP_001398780.1	protein kinase C and casein kinase substrate in neurons protein 2 isoform 1
NM_001411852.1	NP_001398781.1	protein kinase C and casein kinase substrate in neurons protein 2 isoform 4
NM_011862.4	NP_035992.1	protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytoskeletal protein binding	IDA IDA: Inferred from direct assay	11082044	MGI
enables lipid binding	IDA IDA: Inferred from direct assay	20188097	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11082044	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell projection morphogenesis	IMP IMP: Inferred from mutant phenotype	20188097	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	23918399	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	23918399	MGI
acts upstream of or within negative regulation of endocytosis	IDA IDA: Inferred from direct assay	11082044	MGI
involved in plasma membrane tubulation	IMP IMP: Inferred from mutant phenotype	20188097	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in caveola	IDA IDA: Inferred from direct assay	21610094	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	23793062	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	11082044	MGI
located in cytosol	IDA IDA: Inferred from direct assay	10431838	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23918399	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	23918399	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	20188097	MGI
NOT located in trans-Golgi network	IDA IDA: Inferred from direct assay	11082044	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein kinase C and casein kinase substrate in neurons protein 2

Syndapin II	syndapin-2
syndapin-II

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09958	PACSIN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22015	Pacsin2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pacsin2	NCBI	NCBI:11252

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