Pacsin1 - protein kinase C and casein kinase substrate in neurons 1 Gene

Mus musculus

Also known as H74; syndapin; mKIAA1379; A830061D09Rik

Gene ID: 23969 | Gene type: protein coding

About Pacsin1

Summary

Enables cytoskeletal protein binding activity; identical protein binding activity; and phospholipid binding activity. Involved in plasma membrane tubulation; protein localization to membrane; and synaptic vesicle endocytosis. Acts upstream of or within negative regulation of endocytosis. Located in COPI-coated vesicle and ruffle membrane. Is active in photoreceptor ribbon synapse and presynaptic endocytic zone. Is expressed in central nervous system; dorsal root ganglion; nasal cavity epithelium; and retina. Orthologous to human PACSIN1 (protein kinase C and Casein Kinase substrate in neurons 1). [provided by Alliance of Genome Resources, Apr 2022]

Pacsin1 Products(4)

mRNA	Protein	Name
NM_001286743.1	NP_001273672.1	protein kinase C and casein kinase substrate in neurons protein 1
NM_001286744.1	NP_001273673.1	protein kinase C and casein kinase substrate in neurons protein 1
NM_011861.3	NP_035991.1	protein kinase C and casein kinase substrate in neurons protein 1
NM_178365.4	NP_848142.1	protein kinase C and casein kinase substrate in neurons protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytoskeletal protein binding	IDA IDA: Inferred from direct assay	11082044	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	20404169	MGI
enables phospholipid binding	IDA IDA: Inferred from direct assay	20404169	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11082044	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of endocytosis	IDA IDA: Inferred from direct assay	11082044	MGI
involved in plasma membrane tubulation	IMP IMP: Inferred from mutant phenotype	20404169	MGI
involved in protein localization to membrane	IMP IMP: Inferred from mutant phenotype	21926968	MGI
involved in synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	21926968	MGI
involved in synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	21926968	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in COPI-coated vesicle	IDA IDA: Inferred from direct assay	9746365	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	11082044	MGI
is active in photoreceptor ribbon synapse	IDA IDA: Inferred from direct assay	23785143	MGI
is active in presynaptic endocytic zone	IDA IDA: Inferred from direct assay	23785143	MGI
located in ruffle membrane	IDA IDA: Inferred from direct assay	20404169	MGI
NOT located in trans-Golgi network	IDA IDA: Inferred from direct assay	11082044	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein kinase C and casein kinase substrate in neurons protein 1

Syndapin I

syndapin-1

Pacsin1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Pacsin1	Q61644	Mapt	Mus musculus	P10637	IF	23035120
Intra	Pacsin1	Q61644	Pacsin1	Mus musculus	Q61644	X-Ray Diffraction	20404169
Intra	Pacsin1	Q61644	DNM1	Homo sapiens	Q05193	Pull Down	20404169
Intra	Pacsin1	Q61644	Mapt	Mus musculus	P10637	Pull Down	23035120
Intra	Pacsin1	Q61644	Dnm2	Mus musculus	P39054	Anti Bait CoIP	21926968
Intra	Pacsin1	Q61644	Dnm3	Mus musculus	Q8BZ98	Anti Bait CoIP	21926968
Intra	Pacsin1	Q61644	Dnm1	Mus musculus	P39053	Anti Bait CoIP	21926968
Intra	Pacsin1	Q61644	Pacsin1	Mus musculus	Q61644	Pull Down	20404169
Cross	Pacsin1	Q61644	Mapt	Rattus norvegicus	P19332-5	Anti Bait CoIP	23035120
Cross	Pacsin1	Q61644	Mapt	Rattus norvegicus	P19332-5	Pull Down	23035120

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09957	PACSIN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19839	Pacsin1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26336	Pacsin1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pacsin1	NCBI	NCBI:29993

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