2. Gene
  3. Impdh1 - inosine monophosphate dehydrogenase 1 Gene

Impdh1 - inosine monophosphate dehydrogenase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as IMPDH-I; B930086D20Rik

Gene ID: 23917 | Gene type: protein coding

About Impdh1

Summary

Enables IMP dehydrogenase activity. Involved in 'de novo' XMP biosynthetic process and GMP biosynthetic process. Acts upstream of or within lymphocyte proliferation and purine nucleotide biosynthetic process. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Is expressed in central nervous system and retina outer nuclear layer. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 11; retinitis pigmentosa; and retinitis pigmentosa 10. Orthologous to human IMPDH1 (inosine monophosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Impdh1 Products(3)

mRNA Protein Name
NM_001302933.1 NP_001289862.1 inosine-5'-monophosphate dehydrogenase 1 isoform 1
NM_001302934.1 NP_001289863.1 inosine-5'-monophosphate dehydrogenase 1 isoform 2
NM_011829.3 NP_035959.2 inosine-5'-monophosphate dehydrogenase 1 isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables IMP dehydrogenase activity IDA
IDA: Inferred from direct assay
12944494 MGI
Biological Process GO Annotation Evidence Reference Source
involved in 'de novo' XMP biosynthetic process IMP
IMP: Inferred from mutant phenotype
12944494 MGI
involved in GMP biosynthetic process IMP
IMP: Inferred from mutant phenotype
12944494 MGI
acts upstream of or within lymphocyte proliferation IMP
IMP: Inferred from mutant phenotype
12944494 MGI
acts upstream of or within purine nucleotide biosynthetic process IMP
IMP: Inferred from mutant phenotype
12944494 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inosine-5'-monophosphate dehydrogenase 1

IMP dehydrogenase 1

IMPD 1

IMPDH 1

inosine 5'-phosphate dehydrogenase 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114570 Tiazofurin Inhibitor 99.84% Unkown
HY-169296 IMPDH2-IN-4 / Unkown
HY-RS06798 IMPDH1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-164434 Xanthosine-5'-monophosphate / Unkown
HY-RS17781 Impdh1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24248 Impdh1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Impdh1 NCBI NCBI:3614