2. Gene
  3. Usp3 - ubiquitin specific peptidase 3 Gene

Usp3 - ubiquitin specific peptidase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 235441 | Gene type: protein coding

About Usp3

Summary

The protein encoded by this gene is a chromatin-associated histone 2A and 2B deubiquitinating enzyme that negatively regulates the DNA damage response. Mice deficient for this enzyme have reduced hematopoietic stem cell reserves, demonstrating a requirement in hematopoietic stem cell homeostasis. In addition, knock down of protein levels results in spontaneous tumor development and shortened lifespan, consistent with a function in preserving chromosomal integrity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Usp3 Products(3)

mRNA Protein Name
NM_001302116.1 NP_001289045.1 ubiquitin carboxyl-terminal hydrolase 3 isoform 2
NM_001302122.1 NP_001289051.1 ubiquitin carboxyl-terminal hydrolase 3 isoform 3
NM_144937.4 NP_659186.1 ubiquitin carboxyl-terminal hydrolase 3 isoform 1
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 3

deubiquitinating enzyme 3

ubiquitin specific protease 3

ubiquitin thioesterase 3

ubiquitin thiolesterase 3

ubiquitin-specific-processing protease 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-157428 USP3 ZnF-UBD ligand-1 99.61% Unkown
HY-RS15540 USP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17498 Usp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23955 Usp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Usp3 NCBI NCBI:9960