Micall2 - MICAL-like 2 Gene

Mus musculus

Also known as JRAB; MICAL-L2; mFLJ00139; A930021H16Rik

Gene ID: 231830 | Gene type: protein coding

About Micall2

Summary

Enables cytoskeletal protein binding activity and small GTPase binding activity. Involved in several processes, including actin Cytoskeleton organization; bicellular tight junction assembly; and substrate adhesion-dependent cell spreading. Acts upstream of or within endocytic recycling. Located in several cellular components, including actin filament bundle; bicellular tight junction; and recycling endosome. Colocalizes with stress fiber. Is expressed in several structures, including chondrocranium; liver lobe; medulla oblongata basal plate; submandibular gland primordium; and vibrissa. Orthologous to human MICALL2 (MICAL like 2). [provided by Alliance of Genome Resources, Apr 2022]

Micall2 Products(1)

mRNA	Protein	Name
NM_174850.3	NP_777275.2	MICAL-like protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin filament binding	IDA IDA: Inferred from direct assay	18332111	MGI
enables actinin binding	IPI IPI: Inferred from physical interaction	23890175	MGI
enables filamin binding	IDA IDA: Inferred from direct assay	23890175	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16525024	MGI
enables small GTPase binding	IPI IPI: Inferred from physical interaction	18094055	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	23890175	MGI
involved in actin filament polymerization	IMP IMP: Inferred from mutant phenotype	20008558	MGI
involved in bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	18094055	MGI
acts upstream of or within endocytic recycling	IDA IDA: Inferred from direct assay	16525024	MGI
involved in endocytic recycling	IMP IMP: Inferred from mutant phenotype	18094055	MGI
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	20008558	MGI
involved in substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	23890175	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin filament bundle	IDA IDA: Inferred from direct assay	16525024	MGI
located in bicellular tight junction	IDA IDA: Inferred from direct assay	16525024	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	18332111	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	18094055	MGI
located in recycling endosome	IDA IDA: Inferred from direct assay	18094055	MGI
colocalizes with stress fiber	IDA IDA: Inferred from direct assay	23890175	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

MICAL-like protein 2

junctional Rab13-binding protein

molecule interacting with CasL-like 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08429	MICALL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22011	Micall2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Micall2	NCBI	NCBI:79778

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