Asxl1 - ASXL transcriptional regulator 1 Gene

Mus musculus

Gene ID: 228790 | Gene type: protein coding

About Asxl1

Summary

Enables peroxisome proliferator activated receptor binding activity; retinoic acid receptor binding activity; and transcription coactivator activity. Involved in several processes, including kidney development; negative regulation of fat cell differentiation; and regulation of signal transduction. Acts upstream of or within animal organ development; cell morphogenesis; and homeostasis of number of cells. Located in nucleus. Is expressed in several structures, including limb bud; lung; nervous system; paraxial mesenchyme; and salivary gland. Used to study acute myeloid leukemia; myelodysplastic syndrome; and myeloproliferative neoplasm. Human ortholog(s) of this gene implicated in SM-AHNMD; acute myeloid leukemia; chronic myelomonocytic leukemia; myelodysplastic syndrome; and myelofibrosis. Orthologous to human ASXL1 (ASXL transcriptional regulator 1). [provided by Alliance of Genome Resources, Apr 2022]

Asxl1 Products(1)

mRNA	Protein	Name
NM_001039939.2	NP_001035028.1	polycomb group protein ASXL1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear retinoic acid receptor binding	IDA IDA: Inferred from direct assay	16606617	MGI
enables peroxisome proliferator activated receptor binding	IDA IDA: Inferred from direct assay	21047783	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16606617	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	16606617	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	19861679	MGI
acts upstream of or within bone development	IMP IMP: Inferred from mutant phenotype	22876197	MGI
acts upstream of or within bone marrow development	IMP IMP: Inferred from mutant phenotype	19861679	MGI
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	19861679	MGI
acts upstream of or within heart morphogenesis	IMP IMP: Inferred from mutant phenotype	24860998	MGI
acts upstream of or within hematopoietic or lymphoid organ development	IMP IMP: Inferred from mutant phenotype	19861679	MGI
acts upstream of or within hemopoiesis	IMP IMP: Inferred from mutant phenotype	19861679	MGI
acts upstream of or within homeostasis of number of cells	IMP IMP: Inferred from mutant phenotype	19861679	MGI
acts upstream of or within lung saccule development	IMP IMP: Inferred from mutant phenotype	24860998	MGI
involved in negative regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	21047783	MGI
involved in negative regulation of peroxisome proliferator activated receptor signaling pathway	IDA IDA: Inferred from direct assay	21047783	MGI
involved in podocyte development	IMP IMP: Inferred from mutant phenotype	26385183	MGI
involved in positive regulation of retinoic acid receptor signaling pathway	IDA IDA: Inferred from direct assay	16606617	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16606617	MGI
involved in regulation of kidney size	IMP IMP: Inferred from mutant phenotype	26385183	MGI
involved in response to retinoic acid	IDA IDA: Inferred from direct assay	16606617	MGI
acts upstream of or within thymus development	IMP IMP: Inferred from mutant phenotype	19861679	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	24216483	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

polycomb group protein ASXL1

additional sex combs like 1	additional sex combs-like protein 1
putative Polycomb group protein ASXL1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W327122	BAP1-IN-1	Inhibitor	99.86%	Unkown
HY-RS01114	ASXL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17970	Asxl1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24441	Asxl1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Asxl1	NCBI	NCBI:171023

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