2. Gene
  3. Gsn - gelsolin Gene

Gsn - gelsolin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ADF

Gene ID: 227753 | Gene type: protein coding

About Gsn

Summary

Enables phosphatidylinositol 3-kinase catalytic subunit binding activity. Involved in several processes, including actin filament capping; actin polymerization or depolymerization; and positive regulation of protein processing in phagocytic vesicle. Acts upstream of or within cellular response to interferon-gamma and vesicle-mediated transport. Located in lamellipodium and phagocytic vesicle. Colocalizes with focal adhesion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Finnish type amyloidosis. Orthologous to human GSN (gelsolin). [provided by Alliance of Genome Resources, Apr 2022]

Gsn Products(7)

mRNA Protein Name
NM_001206367.1 NP_001193296.1 gelsolin isoform 2
NM_001206368.1 NP_001193297.1 gelsolin isoform 2
NM_001206369.1 NP_001193298.1 gelsolin isoform 2
NM_001362945.1 NP_001349874.1 gelsolin isoform 3
NM_001362947.1 NP_001349876.1 gelsolin isoform 3
NM_001362948.1 NP_001349877.1 gelsolin isoform 2
NM_146120.4 NP_666232.2 gelsolin isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables phosphatidylinositol 3-kinase catalytic subunit binding IPI
IPI: Inferred from physical interaction
30568254 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23055941 MGI
Biological Process GO Annotation Evidence Reference Source
involved in actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
30568254 MGI
involved in actin filament capping IDA
IDA: Inferred from direct assay
23325791 MGI
involved in actin filament depolymerization IMP
IMP: Inferred from mutant phenotype
30568254 MGI
involved in actin filament polymerization IDA
IDA: Inferred from direct assay
23325791 MGI
involved in actin filament severing IMP
IMP: Inferred from mutant phenotype
23325791 MGI
involved in cardiac muscle cell contraction IMP
IMP: Inferred from mutant phenotype
30568254 MGI
acts upstream of or within cellular response to type II interferon IDA
IDA: Inferred from direct assay
19144319 MGI
involved in phagocytosis, engulfment IMP
IMP: Inferred from mutant phenotype
23325791 MGI
involved in positive regulation of protein processing in phagocytic vesicle IMP
IMP: Inferred from mutant phenotype
23325791 MGI
involved in relaxation of cardiac muscle IMP
IMP: Inferred from mutant phenotype
30568254 MGI
involved in response to muscle stretch IMP
IMP: Inferred from mutant phenotype
30568254 MGI
acts upstream of or within vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
11514591 MGI
Cellular Component GO Annotation Evidence Reference Source
colocalizes with focal adhesion IDA
IDA: Inferred from direct assay
23325791 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
15294161 MGI
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
19144319 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gelsolin

actin-depolymerizing factor

brevin

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-133870 Itaconate-alkyne 98.01% Unkown
HY-RS05867 GSN Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18449 Gsn Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24931 Gsn Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gsn NCBI NCBI:2934