Zfpm1 - zinc finger protein, multitype 1 Gene

Mus musculus

Also known as FOG; Fog1

Gene ID: 22761 | Gene type: protein coding

About Zfpm1

Summary

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including embryonic hemopoiesis; heart development; and negative regulation of cell differentiation. Acts upstream of or within several processes, including myeloid cell differentiation; regulation of chemokine production; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and integumental system. Orthologous to human ZFPM1 (Zinc Finger Protein, FOG family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Zfpm1 Products(1)

mRNA	Protein	Name
NM_009569.4	NP_033595.1	zinc finger protein ZFPM1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	9230307	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9230307	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in atrial septum morphogenesis	IMP IMP: Inferred from mutant phenotype	14614148	MGI
involved in atrioventricular valve morphogenesis	IMP IMP: Inferred from mutant phenotype	14614148	MGI
involved in cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	14614148	MGI
acts upstream of or within definitive erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	9553047	MGI
involved in embryonic hemopoiesis	IMP IMP: Inferred from mutant phenotype	14614148	MGI
acts upstream of or within erythrocyte differentiation	IGI IGI: Inferred from genetic interaction	9230307	MGI
acts upstream of or within erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	20010697	MGI
acts upstream of or within granulocyte differentiation	IMP IMP: Inferred from mutant phenotype	20010697	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	14614148	MGI
acts upstream of or within homeostasis of number of cells	IMP IMP: Inferred from mutant phenotype	20643340	MGI
acts upstream of or within megakaryocyte development	IMP IMP: Inferred from mutant phenotype	20010697	MGI
acts upstream of or within megakaryocyte differentiation	IGI IGI: Inferred from genetic interaction	9230307	MGI
acts upstream of or within megakaryocyte differentiation	IMP IMP: Inferred from mutant phenotype	9553047	MGI
involved in mitral valve formation	IMP IMP: Inferred from mutant phenotype	14614148	MGI
involved in negative regulation of mast cell differentiation	IDA IDA: Inferred from direct assay	18063754	MGI
involved in negative regulation of protein binding	IDA IDA: Inferred from direct assay	18063754	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	2906112	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20010697	MGI
involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	14614148	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9230307	MGI
acts upstream of or within primitive erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	9553047	MGI
acts upstream of or within regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	20643340	MGI
involved in tricuspid valve formation	IMP IMP: Inferred from mutant phenotype	14614148	MGI
involved in ventricular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	14614148	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12213678	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

zinc finger protein ZFPM1

FOG-1	Friend of GATA 1
friend of GATA protein 1

Zfpm1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Zfpm1	O35615	Kdm1a	Mus musculus	Q6ZQ88	Anti Tag CoIP	19654328
Intra	Zfpm1	O35615	Kdm1a	Mus musculus	Q6ZQ88	TAP	19654328
Intra	Zfpm1	O35615	Tacc3	Mus musculus	Q9JJ11	Y2H	15234987
Intra	Zfpm1	O35615	Tacc3	Mus musculus	Q9JJ11	NMR	15234987
Intra	Zfpm1	O35615	Tacc3	Mus musculus	Q9JJ11	Anti Tag CoIP	15234987
Intra	Zfpm1	O35615	Gata1	Mus musculus	P17679	Anti Bait CoIP	19513100
Intra	Zfpm1	O35615	Gata1	Mus musculus	P17679	TAP	19654328
Intra	Zfpm1	O35615	Gata1	Mus musculus	P17679	Anti Bait CoIP	19654328
Intra	Zfpm1	O35615	Gata1	Mus musculus	P17679	Y2H	15234987
Cross	Zfpm1	O35615	GATA1	Homo sapiens	P15976	Pull Down	11675338
Cross	Zfpm1	O35615	GATA1	Homo sapiens	P15976	Y2H	11675338

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16048	ZFPM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19759	Zfpm1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26256	Zfpm1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Zfpm1	NCBI	NCBI:161882

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