Ndufs2 - NADH:ubiquinone oxidoreductase core subunit S2 Gene

Mus musculus

Also known as CI-49kD

Gene ID: 226646 | Gene type: protein coding

About Ndufs2

Summary

Enables NADH dehydrogenase (ubiquinone) activity and oxygen sensor activity. Involved in several processes, including cellular response to oxygen levels; gliogenesis; and mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; inherited metabolic disorder; multiple sclerosis; and nuclear type mitochondrial complex I deficiency 6. Orthologous to human NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2). [provided by Alliance of Genome Resources, Apr 2022]

Ndufs2 Products(2)

mRNA	Protein	Name
NM_153064.5	NP_694704.1	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor
NM_153064.5	NP_694704.1	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables NADH dehydrogenase (ubiquinone) activity	IMP IMP: Inferred from mutant phenotype	26437605	MGI
enables oxygen sensor activity	IMP IMP: Inferred from mutant phenotype	26437605	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	32279995	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to oxygen levels	IMP IMP: Inferred from mutant phenotype	26437605	MGI
involved in gliogenesis	IMP IMP: Inferred from mutant phenotype	31297047	MGI
involved in mitochondrial respiratory chain complex I assembly	IMP IMP: Inferred from mutant phenotype	26437605	MGI
involved in neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	31297047	MGI
involved in neurogenesis	IMP IMP: Inferred from mutant phenotype	31297047	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

NADH dehydrogenase (ubiquinone) Fe-S protein 2	NADH-coenzyme Q reductase
NADH-ubiquinone oxidoreductase 49 kDa subunit	complex I-49kD

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09158	NDUFS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21898	Ndufs2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ndufs2	NCBI	NCBI:4720

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