Zap70 - zeta-chain (TCR) associated protein kinase Gene

Mus musculus

Also known as Srk; mur; mrtle; ZAP-70

Gene ID: 22637 | Gene type: protein coding

About Zap70

Summary

This gene encodes a member of the protein tyrosine kinase family. The encoded protein is essential for development of T lymphocytes and thymocytes, and functions in the initial step of T lymphocyte receptor-mediated signal transduction. A mutation in this gene causes chronic autoimmune arthritis, similar to rheumatoid arthritis in humans. Mice lacking this gene are deficient in alpha-beta T lymphocytes in the thymus. In humans, mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T lymphocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Zap70 Products(4)

mRNA	Protein	Name
NM_001289612.1	NP_001276541.1	tyrosine-protein kinase ZAP-70 isoform TZK
NM_001289765.1	NP_001276694.1	tyrosine-protein kinase ZAP-70 isoform a
NM_001289766.1	NP_001276695.1	tyrosine-protein kinase ZAP-70 isoform b
NM_009539.3	NP_033565.2	tyrosine-protein kinase ZAP-70 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	8798454	MGI
enables phosphotyrosine residue binding	IPI IPI: Inferred from physical interaction	8196616	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8551236	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	14738763	MGI
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	8798454	MGI
enables protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	9208839	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of T cell differentiation	IMP IMP: Inferred from mutant phenotype	9208839	MGI
acts upstream of or within T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9208839	MGI
acts upstream of alpha-beta T cell differentiation	IGI IGI: Inferred from genetic interaction	9275205	MGI
acts upstream of alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	7630421	MGI
acts upstream of or within beta selection	IGI IGI: Inferred from genetic interaction	9275205	MGI
acts upstream of calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	7630421	MGI
acts upstream of or within intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	7630421	MGI
acts upstream of or within negative thymic T cell selection	IMP IMP: Inferred from mutant phenotype	7630421	MGI
acts upstream of or within peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	8798454	MGI
acts upstream of or within peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	9208839	MGI
acts upstream of or within positive regulation of T cell differentiation	IMP IMP: Inferred from mutant phenotype	9208839	MGI
acts upstream of or within positive regulation of alpha-beta T cell differentiation	IGI IGI: Inferred from genetic interaction	9275205	MGI
acts upstream of or within positive regulation of alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	7630421	MGI
acts upstream of or within positive regulation of alpha-beta T cell proliferation	IGI IGI: Inferred from genetic interaction	9275205	MGI
acts upstream of or within positive regulation of calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	7630421	MGI
acts upstream of or within positive thymic T cell selection	IMP IMP: Inferred from mutant phenotype	7630421	MGI
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	8798454	MGI
acts upstream of or within protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	9208839	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	9169414	MGI
acts upstream of or within thymic T cell selection	IMP IMP: Inferred from mutant phenotype	9208839	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	23793062	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	17028588	MGI
located in cytosol	IDA IDA: Inferred from direct assay	9182527	MGI
located in immunological synapse	IDA IDA: Inferred from direct assay	17028588	MGI
located in membrane	IDA IDA: Inferred from direct assay	15599401	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17028588	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tyrosine-protein kinase ZAP-70

70 kDa zeta-chain associated protein

syk-related tyrosine kinase

Zap70 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Zap70	P43404	Cd247	Mus musculus	P24161	Anti Bait CoIP	24034254
Intra	Zap70	P43404	Cd247	Mus musculus	P24161	Affinity Chrom	24584089

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15322	PRT062607	Inhibitor	99.38%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136179	ZAP-180013	Inhibitor	99.88%	Unkown
HY-155978A	RDN2150 TFA	Inhibitor	99.80%	Unkown
HY-155978	RDN2150	Inhibitor	/	Unkown
HY-112319	MK-8457	Inhibitor	/	Unkown
HY-RS15951	ZAP70 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17310	Zap70 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23765	Zap70 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99129	Anti-Mouse CD8a Antibody (53-6.7)	Inhibitor	95.00%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Zap70	NCBI	NCBI:7535

Name
Email *

	Sorry, but the email address you supplied was invalid.