Xpc - xeroderma pigmentosum, complementation group C Gene

Mus musculus

Gene ID: 22591 | Gene type: protein coding

About Xpc

Summary

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and damaged DNA binding activity. Involved in UV-damage excision repair. Acts upstream of or within mitotic intra-S DNA damage checkpoint signaling; pyrimidine dimer repair by nucleotide-excision repair; and response to UV. Located in nucleus and site of DNA damage. Used to study lung Cancer and xeroderma pigmentosum group C. Human ortholog(s) of this gene implicated in pancreatic cancer; serous cystadenocarcinoma; xeroderma pigmentosum; and xeroderma pigmentosum group C. Orthologous to human XPC (XPC complex subunit, DNA damage recognition and repair factor). [provided by Alliance of Genome Resources, Apr 2022]

Xpc Products(1)

mRNA	Protein	Name
NM_009531.2	NP_033557.2	DNA repair protein complementing XP-C cells homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	25901318	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	25901318	MGI
enables damaged DNA binding	IDA IDA: Inferred from direct assay	22431748	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22431748	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA damage response	IMP IMP: Inferred from mutant phenotype	15010313	MGI
acts upstream of or within DNA repair	IMP IMP: Inferred from mutant phenotype	12555660	MGI
involved in UV-damage excision repair	IDA IDA: Inferred from direct assay	22431748	MGI
acts upstream of or within mitotic intra-S DNA damage checkpoint signaling	IGI IGI: Inferred from genetic interaction	15533840	MGI
acts upstream of or within nucleotide-excision repair	IDA IDA: Inferred from direct assay	12815074	MGI
involved in nucleotide-excision repair	IDA IDA: Inferred from direct assay	22431748	MGI
acts upstream of or within nucleotide-excision repair	IMP IMP: Inferred from mutant phenotype	9067411	MGI
acts upstream of or within pyrimidine dimer repair by nucleotide-excision repair	IMP IMP: Inferred from mutant phenotype	17049932	MGI
acts upstream of or within response to UV-B	IMP IMP: Inferred from mutant phenotype	15010313	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12815074	MGI
is active in site of DNA damage	IDA IDA: Inferred from direct assay	22431748	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

DNA repair protein complementing XP-C cells homolog

p125	xeroderma pigmentosum group C-complementing protein homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-157784	XPC-7724	Inhibitor	/	Unkown
HY-128772	XPC-6444	Inhibitor	98.85%	Unkown
HY-157786	XPC-5462	Inhibitor	/	Unkown
HY-RS15885	XPC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20245	Xpc Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26753	Xpc Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Xpc	NCBI	NCBI:7508

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