Myrf - myelin regulatory factor Gene

Mus musculus

Also known as Mrf; Gm98; Gm1804; 6030439E18

Gene ID: 225908 | Gene type: protein coding

About Myrf

Summary

Enables DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including central nervous system myelin maintenance; positive regulation of myelination; and regulation of transcription, DNA-templated. Located in endoplasmic reticulum membrane and nucleus. Is expressed in pigmented retinal epithelium; spinal cord; and spinal cord marginal layer. Orthologous to human MYRF (myelin regulatory factor). [provided by Alliance of Genome Resources, Apr 2022]

Myrf Products(2)

mRNA	Protein	Name
NM_001033481.2	NP_001028653.1	myelin regulatory factor isoform 1
NM_001404113.1	NP_001391042.1	myelin regulatory factor isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	24204311	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	24204311	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	31828317	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	30249802	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in central nervous system myelin maintenance	IMP IMP: Inferred from mutant phenotype	22956843	MGI
involved in central nervous system myelination	IMP IMP: Inferred from mutant phenotype	19596243	MGI
involved in oligodendrocyte development	IDA IDA: Inferred from direct assay	31828317	MGI
involved in oligodendrocyte development	IMP IMP: Inferred from mutant phenotype	19596243	MGI
involved in oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	22956843	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	19596243	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	22956843	MGI
involved in positive regulation of myelination	IMP IMP: Inferred from mutant phenotype	19596243	MGI
involved in protein autoprocessing	IDA IDA: Inferred from direct assay	30249802	MGI
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	31828317	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	30249802	MGI
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	30249802	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19596243	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

myelin regulatory factor

myelin gene regulatory factor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08969	MYRF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18955	Myrf Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25445	Myrf Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myrf	NCBI	NCBI:745

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