2. Gene
  3. Xpa - xeroderma pigmentosum, complementation group A Gene

Xpa - xeroderma pigmentosum, complementation group A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Xpac

Gene ID: 22590 | Gene type: protein coding

About Xpa

Summary

Predicted to enable DNA binding activity; protein domain specific binding activity; and protein homodimerization activity. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; nucleotide-excision repair; and positive regulation of transcription initiation from RNA polymerase II promoter. Located in nucleus. Is expressed in forelimb bud. Used to study xeroderma pigmentosum group A. Human ortholog(s) of this gene implicated in xeroderma pigmentosum and xeroderma pigmentosum group A. Orthologous to human XPA (XPA, DNA damage recognition and repair factor). [provided by Alliance of Genome Resources, Apr 2022]

Xpa Products(1)

mRNA Protein Name
NM_011728.2 NP_035858.2 DNA repair protein complementing XP-A cells homolog
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within DNA repair IMP
IMP: Inferred from mutant phenotype
9661901 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
11005836 MGI
acts upstream of or within multicellular organism growth IGI
IGI: Inferred from genetic interaction
22323595 MGI
acts upstream of or within nucleotide-excision repair IMP
IMP: Inferred from mutant phenotype
11950998 MGI
acts upstream of or within positive regulation of transcription initiation by RNA polymerase II IGI
IGI: Inferred from genetic interaction
22323595 MGI
acts upstream of or within regulation of autophagy IMP
IMP: Inferred from mutant phenotype
18443001 MGI
acts upstream of or within response to UV IMP
IMP: Inferred from mutant phenotype
10843671 MGI
acts upstream of or within response to oxidative stress IMP
IMP: Inferred from mutant phenotype
11950998 MGI
acts upstream of or within response to toxic substance IMP
IMP: Inferred from mutant phenotype
11408355 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
12815074 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA repair protein complementing XP-A cells homolog

xeroderma pigmentosum group A-complementing protein homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-139038 TDRL-X80 99.6% Unkown
HY-161623 ERCC1/XPA interaction inhibitor 1 Inhibitor / Unkown
HY-RS15884 XPA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22088 Xpa Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28608 Xpa Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Xpa NCBI NCBI:7507