2. Gene
  3. Eppk1 - epiplakin 1 Gene

Eppk1 - epiplakin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as EPPK; EPIPL; EPIPL1; 6230424I18Rik

Gene ID: 223650 | Gene type: protein coding

About Eppk1

Summary

Enables keratin filament binding activity. Involved in several processes, including intermediate filament bundle assembly; negative regulation of keratinocyte migration; and regulation of epithelial cell proliferation. Located in several cellular components, including apicolateral plasma membrane; basal part of cell; and cell-cell junction. Colocalizes with keratin filament. Is expressed in several structures, including alimentary system; liver and biliary system; respiratory system; sensory organ; and skin. Orthologous to human EPPK1 (epiplakin 1). [provided by Alliance of Genome Resources, Apr 2022]

Eppk1 Products(1)

mRNA Protein Name
NM_144848.2 NP_659097.2 epiplakin
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables keratin filament binding IPI
IPI: Inferred from physical interaction
18285451 MGI
Biological Process GO Annotation Evidence Reference Source
involved in cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
23599337 MGI
involved in intermediate filament bundle assembly IMP
IMP: Inferred from mutant phenotype
20926261 MGI
involved in intermediate filament organization IDA
IDA: Inferred from direct assay
25617501 MGI
involved in intermediate filament organization IMP
IMP: Inferred from mutant phenotype
18285451 MGI
involved in negative regulation of keratinocyte migration IMP
IMP: Inferred from mutant phenotype
16382146 MGI
involved in negative regulation of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
16382146 MGI
involved in negative regulation of wound healing IMP
IMP: Inferred from mutant phenotype
20926261 MGI
involved in positive regulation of epithelial cell proliferation involved in wound healing IMP
IMP: Inferred from mutant phenotype
23599337 MGI
involved in regulation of epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
23599337 MGI
involved in regulation of epithelium regeneration IMP
IMP: Inferred from mutant phenotype
16382146 MGI
Cellular Component GO Annotation Evidence Reference Source
located in apicolateral plasma membrane IDA
IDA: Inferred from direct assay
25232867 MGI
located in basal part of cell IDA
IDA: Inferred from direct assay
23599337 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
23599337 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12791695 MGI
located in cytoskeleton IDA
IDA: Inferred from direct assay
25617501 MGI
colocalizes with keratin filament IDA
IDA: Inferred from direct assay
18285451 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

epiplakin

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04450 EPPK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07472 KRT9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20399 Eppk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26908 Eppk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eppk1 NCBI NCBI:83481