2. Gene
  3. Vdac1 - voltage-dependent anion channel 1 Gene

Vdac1 - voltage-dependent anion channel 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Vdac5; mVDAC1; mVDAC5

Gene ID: 22333 | Gene type: protein coding

About Vdac1

Summary

This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Multiple pseudogenes of this gene are found on chromosomes 1, 2, 3, 6, 8, 9, and X. [provided by RefSeq, Sep 2015]

Vdac1 Products(6)

mRNA Protein Name
NM_001362693.2 NP_001349622.1 voltage-dependent anion-selective channel protein 1 isoform 1
NM_001400986.1 NP_001387915.1 voltage-dependent anion-selective channel protein 1 isoform 3
NM_001400987.1 NP_001387916.1 voltage-dependent anion-selective channel protein 1 isoform 4
NM_001400988.1 NP_001387917.1 voltage-dependent anion-selective channel protein 1 isoform 2
NM_001400989.1 NP_001387918.1 voltage-dependent anion-selective channel protein 1 isoform 2
NM_011694.7 NP_035824.1 voltage-dependent anion-selective channel protein 1 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables oxysterol binding IMP
IMP: Inferred from mutant phenotype
34799735 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22079573 MGI
enables voltage-gated monoatomic anion channel activity IDA
IDA: Inferred from direct assay
18988731 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within behavioral fear response IMP
IMP: Inferred from mutant phenotype
11907043 MGI
acts upstream of or within chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
11907043 MGI
acts upstream of or within learning IMP
IMP: Inferred from mutant phenotype
11907043 MGI
involved in negative regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
25470454 MGI
acts upstream of or within neuron-neuron synaptic transmission IMP
IMP: Inferred from mutant phenotype
11907043 MGI
involved in regulation of mitophagy IMP
IMP: Inferred from mutant phenotype
25470454 MGI
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
18988731 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
17376863 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent anion-selective channel protein 1

outer mitochondrial membrane protein porin 1

plasmalemmal porin

voltage-dependent anion-selective channel protein 5

Related Agents

Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-D0086 DIDS sodium salt Inhibitor 99.13% Unkown
HY-129122 VBIT-4 Inhibitor 99.46% Unkown
HY-108937 NSC 15364 Inhibitor 99.67% Unkown
HY-135885 VBIT-12 Inhibitor 98.87% Unkown
HY-111217 AKOS-22 Inhibitor 99.23% Unkown
HY-RS15629 VDAC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-121693 DIDS Inhibitor / Unkown
HY-135571 VBIT-3 Inhibitor / Unkown
HY-161027 DHP-B Inducer / Unkown
HY-176745 SW016789 Inducer / Unkown
HY-RS16872 Vdac1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23313 Vdac1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vdac1 NCBI NCBI:7416