Vamp8 - vesicle-associated membrane protein 8 Gene

Mus musculus

Also known as Edb; endobrevin

Gene ID: 22320 | Gene type: protein coding

About Vamp8

Summary

Predicted to enable SNAP receptor activity; Chloride Channel Inhibitor activity; and syntaxin binding activity. Involved in SNARE complex assembly and mucus secretion. Acts upstream of or within several processes, including cellular response to interferon-gamma; positive regulation of pancreatic amylase secretion; and zymogen granule exocytosis. Located in several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and lysosome. Part of SNARE complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human VAMP8 (vesicle associated membrane protein 8). [provided by Alliance of Genome Resources, Apr 2022]

Vamp8 Products(1)

mRNA	Protein	Name
NM_016794.3	NP_058074.2	vesicle-associated membrane protein 8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14668490	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in SNARE complex assembly	IDA IDA: Inferred from direct assay	21151919	MGI
acts upstream of or within cellular response to type II interferon	IDA IDA: Inferred from direct assay	19144319	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	18535671	MGI
involved in mucus secretion	IMP IMP: Inferred from mutant phenotype	22144578	MGI
acts upstream of or within positive regulation of pancreatic amylase secretion	IMP IMP: Inferred from mutant phenotype	18535671	MGI
acts upstream of or within regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	18227281	MGI
acts upstream of or within vesicle fusion	IMP IMP: Inferred from mutant phenotype	18535671	MGI
acts upstream of or within zymogen granule exocytosis	IMP IMP: Inferred from mutant phenotype	18535671	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of SNARE complex	IDA IDA: Inferred from direct assay	18535671	MGI
located in basal part of cell	IDA IDA: Inferred from direct assay	18535671	MGI
located in basolateral part of cell	IDA IDA: Inferred from direct assay	18535671	MGI
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	18535671	MGI
located in cell surface	IDA IDA: Inferred from direct assay	21151919	MGI
located in cytosol	IDA IDA: Inferred from direct assay	22589474	MGI
located in lysosome	IDA IDA: Inferred from direct assay	27628032	MGI
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	19144319	MGI
located in secretory granule	IDA IDA: Inferred from direct assay	18321981	MGI
located in zymogen granule	IDA IDA: Inferred from direct assay	18535671	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vesicle-associated membrane protein 8

VAMP-8

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10809	VAMP	Inhibitor	/	Unkown
HY-RS15599	VAMP8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19045	Vamp8 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25535	Vamp8 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vamp8	NCBI	NCBI:8673

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