Vamp2 - vesicle-associated membrane protein 2 Gene

Mus musculus

Also known as Syb2; Syb-2; sybII; Vamp-2

Gene ID: 22318 | Gene type: protein coding

About Vamp2

Summary

Enables Calmodulin binding activity; phospholipid binding activity; and syntaxin-1 binding activity. Involved in secretion by cell and synaptic vesicle endocytosis. Acts upstream of or within several processes, including Golgi to plasma membrane protein transport; cellular response to Insulin stimulus; and long-term synaptic potentiation. Located in several cellular components, including secretory vesicle; storage vacuole; and trans-Golgi network. Part of synaptobrevin 2-SNAP-25-syntaxin-1a complex. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human VAMP2 (vesicle associated membrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Vamp2 Products(1)

mRNA	Protein	Name
NM_009497.3	NP_033523.1	vesicle-associated membrane protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SNARE binding	IDA IDA: Inferred from direct assay	12145198	MGI
enables calmodulin binding	IDA IDA: Inferred from direct assay	12145198	MGI
enables phospholipid binding	IDA IDA: Inferred from direct assay	12145198	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10394363	MGI
enables syntaxin binding	IPI IPI: Inferred from physical interaction	17548353	MGI
enables syntaxin-1 binding	IDA IDA: Inferred from direct assay	18703708	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Golgi to plasma membrane protein transport	IMP IMP: Inferred from mutant phenotype	20582536	MGI
acts upstream of or within calcium-ion regulated exocytosis	IDA IDA: Inferred from direct assay	12145198	MGI
acts upstream of or within calcium-ion regulated exocytosis	IMP IMP: Inferred from mutant phenotype	15920476	MGI
acts upstream of or within cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	18227281	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	15920476	MGI
involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane	IDA IDA: Inferred from direct assay	23395379	MGI
involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	23395379	MGI
involved in hormone secretion	IDA IDA: Inferred from direct assay	24356748	MGI
acts upstream of or within long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	23395379	MGI
acts upstream of or within membrane fusion	IMP IMP: Inferred from mutant phenotype	15920476	MGI
acts upstream of or within positive regulation of intracellular protein transport	IMP IMP: Inferred from mutant phenotype	18227281	MGI
involved in regulated exocytosis	IDA IDA: Inferred from direct assay	24356748	MGI
acts upstream of or within regulation of exocytosis	IDA IDA: Inferred from direct assay	12145198	MGI
acts upstream of or within regulation of vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	18227281	MGI
involved in synaptic vesicle docking	IDA IDA: Inferred from direct assay	25374362	MGI
involved in synaptic vesicle docking	IMP IMP: Inferred from mutant phenotype	25374362	MGI
involved in synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	15475946	MGI
acts upstream of or within synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	11691998	MGI
involved in synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	15475946	MGI
involved in vesicle-mediated transport in synapse	IDA IDA: Inferred from direct assay	23395379	MGI
involved in vesicle-mediated transport in synapse	IMP IMP: Inferred from mutant phenotype	23395379	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of SNARE complex	IDA IDA: Inferred from direct assay	18535671	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	24356748	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	18505797	MGI
located in cytoplasmic vesicle membrane	IDA IDA: Inferred from direct assay	12490950	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23395379	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	23395379	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18827011	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	18505797	MGI
located in secretory granule	IDA IDA: Inferred from direct assay	12145198	MGI
located in storage vacuole	IDA IDA: Inferred from direct assay	21828338	MGI
located in synapse	IDA IDA: Inferred from direct assay	18706977	MGI
located in synaptic vesicle	IDA IDA: Inferred from direct assay	15145078	MGI
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	12192047	MGI
part of synaptobrevin 2-SNAP-25-syntaxin-1a complex	IDA IDA: Inferred from direct assay	21040848	MGI
located in trans-Golgi network	IDA IDA: Inferred from direct assay	18827011	MGI
located in vesicle	IDA IDA: Inferred from direct assay	17313651	MGI
located in zymogen granule membrane	IDA IDA: Inferred from direct assay	12192047	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vesicle-associated membrane protein 2

synaptobrevin II	synaptobrevin-2
vesicle-associated membrane 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10809	VAMP	Inhibitor	/	Unkown
HY-RS15594	VAMP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21080	Vamp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27597	Vamp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vamp2	NCBI	NCBI:6844

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