Usf1 - upstream transcription factor 1 Gene

Mus musculus

Also known as bHLHb11

Gene ID: 22278 | Gene type: protein coding

About Usf1

Summary

This protein encoded by this gene is a member of the basic-Helix-Hoop-Helix-Leucine zipper (bHLH-LZ) family and encodes a protein that can act as a transcription factor. Studies indicate that the basic region interacts with DNA at E-Box motifs, while the helix-loop-helix and leucine zipper domains are involved in dimerization with different partners. This protein is involved in a wide array of biological pathways, including cell cycle regulation, immune response, and responses to ultraviolet radiation. Mice lacking most of the coding exons of this gene often lacked both whiskers and nasal fur, and were prone to epileptic seizures, while mice lacking both this gene and another family member, Usf2, displayed embryonic lethality (PMID:9520440). Mutations in the human ortholog of this gene have been associated with Familial Combined Hyperlipidemia (FCHL) in humans. Pseudogenes of this gene are found on chromosome 11 and the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

Usf1 Products(4)

mRNA	Protein	Name
NM_001305676.1	NP_001292605.1	upstream stimulatory factor 1 isoform 1
NM_001305677.1	NP_001292606.1	upstream stimulatory factor 1 isoform 1
NM_001305678.1	NP_001292607.1	upstream stimulatory factor 1 isoform 2
NM_009480.3	NP_033506.1	upstream stimulatory factor 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15466854	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	9890958	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15466854	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23749757	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	9890958	MGI
involved in glucose mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	9890958	MGI
involved in lipid homeostasis	IMP IMP: Inferred from mutant phenotype	9890958	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15466854	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	9890958	MGI
involved in positive regulation of transcription from RNA polymerase II promoter by glucose	IMP IMP: Inferred from mutant phenotype	9890958	MGI
involved in response to UV	IMP IMP: Inferred from mutant phenotype	15358786	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

upstream stimulatory factor 1

Upstream stimulatory factor 1 (Major late transcription factor 1)

major late transcription factor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15513	USF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19651	Usf1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26144	Usf1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Usf1	NCBI	NCBI:7391

Name
Email *

	Sorry, but the email address you supplied was invalid.