Upp1 - uridine phosphorylase 1 Gene

Mus musculus

Also known as Up; Upp; UPase; UdRPase

Gene ID: 22271 | Gene type: protein coding

About Upp1

Summary

Enables deoxyuridine Phosphorylase activity; thymidine Phosphorylase activity; and uridine Phosphorylase activity. Involved in pyrimidine nucleoside monophosphate metabolic process and uridine catabolic process. Acts upstream of or within pyrimidine nucleotide metabolic process and uridine metabolic process. Located in cytosol. Is expressed in early embryo; extraembryonic ectoderm; nervous system; and sensory organ. Orthologous to human UPP1 (uridine Phosphorylase 1). [provided by Alliance of Genome Resources, Apr 2022]

Upp1 Products(3)

mRNA	Protein	Name
NM_001159401.1	NP_001152873.1	uridine phosphorylase 1
NM_001159402.1	NP_001152874.1	uridine phosphorylase 1
NM_009477.3	NP_033503.2	uridine phosphorylase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables deoxyuridine phosphorylase activity	IDA IDA: Inferred from direct assay	7744869	MGI
NOT enables thymidine phosphorylase activity	IMP IMP: Inferred from mutant phenotype	15772079	MGI
enables thymidine phosphorylase activity	IMP IMP: Inferred from mutant phenotype	12077348	MGI
enables uridine phosphorylase activity	IDA IDA: Inferred from direct assay	7744869	MGI
enables uridine phosphorylase activity	IMP IMP: Inferred from mutant phenotype	11956089	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in CMP catabolic process	IDA IDA: Inferred from direct assay	14715930	MGI
involved in UMP catabolic process	IDA IDA: Inferred from direct assay	7744869	MGI
involved in UMP salvage	IMP IMP: Inferred from mutant phenotype	11956089	MGI
involved in dCMP catabolic process	IDA IDA: Inferred from direct assay	7744869	MGI
NOT involved in dTMP catabolic process	IMP IMP: Inferred from mutant phenotype	15772079	MGI
involved in dTMP catabolic process	IMP IMP: Inferred from mutant phenotype	12077348	MGI
involved in dUMP catabolic process	IDA IDA: Inferred from direct assay	14154460	MGI
acts upstream of or within pyrimidine nucleotide metabolic process	IMP IMP: Inferred from mutant phenotype	15772079	MGI
involved in uridine catabolic process	IDA IDA: Inferred from direct assay	7744869	MGI
acts upstream of or within uridine metabolic process	IMP IMP: Inferred from mutant phenotype	15772079	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytosol	IDA IDA: Inferred from direct assay	7744869	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

uridine phosphorylase 1

UPase 1

urdPase 1

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-106406	Benzylacyclouridine		98.18%	Phase 4

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W008491	TK-112690		99.91%	Unkown
HY-RS15490	UPP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17195	Upp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23647	Upp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Upp1	NCBI	NCBI:7378

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