Ucp2 - uncoupling protein 2 (mitochondrial, proton carrier) Gene

Mus musculus

Also known as UCPH; UCP 2; Slc25a8

Gene ID: 22228 | Gene type: protein coding

About Ucp2

Summary

Predicted to enable Oxidative Phosphorylation uncoupler activity. Involved in positive regulation of cold-induced thermogenesis and regulation of mitochondrial membrane potential. Located in mitochondrion. Is expressed in several structures, including adipose tissue; alimentary system; hemolymphoid system; integumental system; and nose. Used to study polycystic liver disease. Human ortholog(s) of this gene implicated in artery disease (multiple); diabetic neuropathy; end stage renal disease; non-alcoholic fatty liver disease; and obesity. Orthologous to human UCP2 (uncoupling protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Ucp2 Products(1)

mRNA	Protein	Name
NM_011671.5	NP_035801.3	mitochondrial uncoupling protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP binding	IDA IDA: Inferred from direct assay	25127353	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	26919426	MGI
involved in long-chain fatty acid transport	IDA IDA: Inferred from direct assay	25127353	MGI
involved in macrophage differentiation	IMP IMP: Inferred from mutant phenotype	34644537	MGI
involved in mitochondrial fission	IMP IMP: Inferred from mutant phenotype	26919426	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	22956852	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	28130074	MGI
involved in reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	26919426	MGI
involved in regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	22736029	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	34644537	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mitochondrial uncoupling protein 2

solute carrier family 25 member 8

uncoupling protein 2, mitochondrial

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-17389	Genipin	Inhibitor	99.55%	Phase 3
HY-138830	TAK-418	Inhibitor	99.81%	Phase 1

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120160	Darglitazone	Agonist	99.19%	Unkown
HY-120160A	Darglitazone Sodium	Agonist	/	Unkown
HY-RS15411	UCP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17900	Ucp2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24369	Ucp2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ucp2	NCBI	NCBI:7351

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