2. Gene
  3. Tsg101 - tumor susceptibility gene 101 Gene

Tsg101 - tumor susceptibility gene 101 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CC2

Gene ID: 22088 | Gene type: protein coding

About Tsg101

Summary

Enables transcription corepressor activity. Involved in exosomal secretion; positive regulation of ubiquitin-dependent endocytosis; and viral budding. Acts upstream of or within several processes, including keratinocyte differentiation; negative regulation of transcription by RNA polymerase II; and regulation of cell growth. Located in cytoplasm and extracellular exosome. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; limb; and nervous system. Human ortholog(s) of this gene implicated in breast cancer; breast carcinoma; cervix carcinoma; endometrial adenocarcinoma; and prostate Cancer. Orthologous to human TSG101 (tumor susceptibility 101). [provided by Alliance of Genome Resources, Apr 2022]

Tsg101 Products(3)

mRNA Protein Name
NM_001348088.1 NP_001335017.1 tumor susceptibility gene 101 protein isoform 2
NM_001348089.1 NP_001335018.1 tumor susceptibility gene 101 protein isoform 3
NM_021884.4 NP_068684.1 tumor susceptibility gene 101 protein isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10888872 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
10888872 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cell differentiation IDA
IDA: Inferred from direct assay
11943869 MGI
involved in exosomal secretion IMP
IMP: Inferred from mutant phenotype
25392495 MGI
acts upstream of or within keratinocyte differentiation IDA
IDA: Inferred from direct assay
11943869 MGI
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11943869 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10888872 MGI
involved in positive regulation of ubiquitin-dependent endocytosis IMP
IMP: Inferred from mutant phenotype
11916981 MGI
acts upstream of or within regulation of cell cycle IDA
IDA: Inferred from direct assay
11943869 MGI
acts upstream of or within regulation of cell growth IDA
IDA: Inferred from direct assay
11943869 MGI
involved in viral budding IMP
IMP: Inferred from mutant phenotype
15256501 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15256501 MGI
located in extracellular exosome IDA
IDA: Inferred from direct assay
24205035 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor susceptibility gene 101 protein

ESCRT-I complex subunit TSG101

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17421 Tenatoprazole Inhibitor 99.75% Unkown
HY-P10845 KRL74 Inhibitor / Unkown
HY-RS15142 TSG101 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19082 Tsg101 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25573 Tsg101 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P991414 FGI-1011A6 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tsg101 NCBI NCBI:7251