2. Gene
  3. Top2b - topoisomerase (DNA) II beta Gene

Top2b - topoisomerase (DNA) II beta Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Top-2; D230016L12Rik

Gene ID: 21974 | Gene type: protein coding

About Top2b

Summary

Predicted to enable several functions, including enzyme binding activity; protein C-terminus binding activity; and protein heterodimerization activity. Acts upstream of or within axonogenesis; forebrain development; and neuron migration. Located in nucleus. Is expressed in central nervous system; genitourinary system; and retina. Orthologous to human TOP2B (DNA Topoisomerase II beta). [provided by Alliance of Genome Resources, Apr 2022]

Top2b Products(1)

mRNA Protein Name
NM_009409.3 NP_033435.2 DNA topoisomerase 2-beta
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IMP
IMP: Inferred from mutant phenotype
31409799 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21186367 MGI
Biological Process GO Annotation Evidence Reference Source
involved in B cell differentiation IMP
IMP: Inferred from mutant phenotype
31409799 MGI
acts upstream of or within axonogenesis IMP
IMP: Inferred from mutant phenotype
10615047 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
12773624 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
12773624 MGI
Cellular Component GO Annotation Evidence Reference Source
NOT located in chromosome IDA
IDA: Inferred from direct assay
11835579 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9224616 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA topoisomerase 2-beta

DNA topoisomerase II, beta isozyme

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14897 TOP2B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20119 Top2b Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26623 Top2b Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Top2b NCBI NCBI:7155