2. Gene
  3. Tjp2 - tight junction protein 2 Gene

Tjp2 - tight junction protein 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ZO-2

Gene ID: 21873 | Gene type: protein coding

About Tjp2

Summary

Predicted to enable several functions, including cell adhesion molecule binding activity; protein C-terminus binding activity; and protein tyrosine kinase binding activity. Acts upstream of or within TNFSF11-mediated signaling pathway and negative regulation of osteoclast development. Located in nucleus; plasma membrane; and tight junction. Is expressed in several structures, including early embryo; genitourinary system; inner ear; neural ectoderm; and tooth. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 51; disease of metabolism; and progressive familial intrahepatic cholestasis 4. Orthologous to human TJP2 (tight junction protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Tjp2 Products(5)

mRNA Protein Name
NM_001198985.2 NP_001185914.1 tight junction protein ZO-2 isoform 1
NM_001360391.1 NP_001347320.1 tight junction protein ZO-2 isoform 3
NM_001360392.1 NP_001347321.1 tight junction protein ZO-2 isoform 4
NM_001376368.1 NP_001363297.1 tight junction protein ZO-2 isoform 2
NM_011597.5 NP_035727.2 tight junction protein ZO-2 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10601346 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of osteoclast development IMP
IMP: Inferred from mutant phenotype
22437732 MGI
acts upstream of or within negative regulation of tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
22437732 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cell junction IDA
IDA: Inferred from direct assay
12507281 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
25486565 MGI
located in nucleus IDA
IDA: Inferred from direct assay
22437732 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12060405 MGI
located in tight junction IDA
IDA: Inferred from direct assay
24889144 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tight junction protein ZO-2

Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2)

zona occludens protein 2

zonula occludens protein 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14554 TJP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22344 Tjp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tjp2 NCBI NCBI:9414