Timeless - timeless circadian clock 1 Gene

Mus musculus

Also known as tim; Debt69

Gene ID: 21853 | Gene type: protein coding

About Timeless

Summary

The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA Polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and Others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate Cancer, lung Cancer, breast Cancer, and mental disorders. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Timeless Products(4)

mRNA	Protein	Name
NM_001136082.2	NP_001129554.1	protein timeless homolog isoform 1
NM_001164080.1	NP_001157552.1	protein timeless homolog isoform 3
NM_001164081.1	NP_001157553.1	protein timeless homolog isoform 2
NM_011589.2	NP_035719.1	protein timeless homolog isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	12875843	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9856465	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	23418588	MGI
acts upstream of or within branching morphogenesis of an epithelial tube	IMP IMP: Inferred from mutant phenotype	12950082	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	10231394	MGI
acts upstream of or within embryo development	IMP IMP: Inferred from mutant phenotype	10903565	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	12950082	MGI
involved in morphogenesis of an epithelium	IEP IEP: Inferred from expression pattern	10963667	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	23418588	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12875843	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein timeless homolog

mTim	timeless homolog

Timeless Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Timeless	Q9R1X4	Per1	Mus musculus	O35973	Pull Down	10231394
Intra	Timeless	Q9R1X4	Per1	Mus musculus	O35973	Anti Tag CoIP	10231394

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14526	TIMELESS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20675	Timeless Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27186	Timeless Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Timeless	NCBI	NCBI:8914

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