2. Gene
  3. Tia1 - cytotoxic granule-associated RNA binding protein 1 Gene

Tia1 - cytotoxic granule-associated RNA binding protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as TIA-1; mTIA-1; 2310050N03Rik

Gene ID: 21841 | Gene type: protein coding

About Tia1

Summary

Enables mRNA 3'-UTR AU-rich region binding activity. Acts upstream of or within negative regulation of cytokine production and negative regulation of translation. Located in cytoplasmic stress granule and nuclear stress granule. Is expressed in several structures, including alimentary system; central nervous system; metanephros; respiratory system; and sensory organ. Orthologous to human TIA1 (TIA1 cytotoxic granule associated RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Tia1 Products(3)

mRNA Protein Name
NM_001164078.1 NP_001157550.1 cytotoxic granule associated RNA binding protein TIA1 isoform 2
NM_001164079.1 NP_001157551.1 cytotoxic granule associated RNA binding protein TIA1 isoform 3
NM_011585.4 NP_035715.1 cytotoxic granule associated RNA binding protein TIA1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables mRNA 3'-UTR AU-rich region binding IDA
IDA: Inferred from direct assay
10921895 MGI
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
16227602 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
10921895 MGI
involved in negative regulation of translation IDA
IDA: Inferred from direct assay
16227602 MGI
acts upstream of or within negative regulation of translation IMP
IMP: Inferred from mutant phenotype
10921895 MGI
involved in regulation of alternative mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
10938105 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11514562 MGI
located in cytoplasmic stress granule IDA
IDA: Inferred from direct assay
21933836 MGI
located in nuclear stress granule IDA
IDA: Inferred from direct assay
22022532 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12388085 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytotoxic granule associated RNA binding protein TIA1

nucleolysin TIA-1

RNA-binding protein TIA-1

T-cell-restricted intracellular antigen-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14513 TIA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20825 Tia1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27339 Tia1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tia1 NCBI NCBI:7072