Flcn - folliculin Gene

Mus musculus

Also known as Bhd; FLCL; B430214A04Rik

Gene ID: 216805 | Gene type: protein coding

About Flcn

Summary

Predicted to enable GTPase activator activity. Involved in several processes, including energy homeostasis; negative regulation of brown fat cell differentiation; and negative regulation of nitrogen compound metabolic process. Acts upstream of or within with a positive effect on negative regulation of cell population proliferation. Acts upstream of or within several processes, including negative regulation of cell proliferation involved in kidney development; positive regulation of transforming growth factor beta receptor signaling pathway; and regulation of intracellular signal transduction. Predicted to be located in several cellular components, including cilium; lysosomal membrane; and microtubule Cytoskeleton. Predicted to be active in cytosol. Predicted to colocalize with cell-cell contact zone and midbody. Is expressed in several structures, including embryo ectoderm; exocrine gland; extraembryonic component; limb bud; and optic cup. Used to study Birt-Hogg-Dube syndrome and nonpapillary renal cell carcinoma. Human ortholog(s) of this gene implicated in Birt-Hogg-Dube syndrome; colorectal cancer; primary spontaneous pneumothorax; and renal cell carcinoma. Orthologous to human FLCN (folliculin). [provided by Alliance of Genome Resources, Apr 2022]

Flcn Products(3)

mRNA	Protein	Name
NM_001271356.1	NP_001258285.1	folliculin
NM_001271357.1	NP_001258286.1	folliculin
NM_146018.2	NP_666130.1	folliculin

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23582324	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	18182616	MGI
acts upstream of TOR signaling	IMP IMP: Inferred from mutant phenotype	18182616	MGI
acts upstream of cell proliferation involved in kidney development	IMP IMP: Inferred from mutant phenotype	18182616	MGI
involved in cell-cell junction assembly	IMP IMP: Inferred from mutant phenotype	22965878	MGI
involved in energy homeostasis	IMP IMP: Inferred from mutant phenotype	23150719	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	18182616	MGI
acts upstream of or within hemopoiesis	IMP IMP: Inferred from mutant phenotype	21258407	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	21258407	MGI
acts upstream of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21258407	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	21209915	MGI
acts upstream of or within negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	18182616	MGI
acts upstream of or within negative regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	18182616	MGI
involved in negative regulation of brown fat cell differentiation	IMP IMP: Inferred from mutant phenotype	27913603	MGI
acts upstream of or within positive effect negative regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	25775561	MGI
acts upstream of or within negative regulation of cell proliferation involved in kidney development	IMP IMP: Inferred from mutant phenotype	18182616	MGI
involved in negative regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	27151976	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	18182616	MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	19850877	MGI
involved in negative regulation of post-translational protein modification	IMP IMP: Inferred from mutant phenotype	21209915	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21209915	MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	19850877	MGI
acts upstream of or within positive regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	19234517	MGI
acts upstream of or within positive regulation of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21258407	MGI
acts upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21258407	MGI
acts upstream of or within regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	19843504	MGI
acts upstream of or within regulation of pro-B cell differentiation	IMP IMP: Inferred from mutant phenotype	22709692	MGI
acts upstream of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21258407	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

folliculin

birt-Hogg-Dube syndrome protein homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04974	FLCN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21342	Flcn Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Flcn	NCBI	NCBI:201163

Name
Email *

	Sorry, but the email address you supplied was invalid.