Tbx2 - T-box 2 Gene

Mus musculus

Gene ID: 21385 | Gene type: protein coding

About Tbx2

Summary

Enables DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including circulatory system development; embryonic morphogenesis; and negative regulation of heart looping. Acts upstream of or within several processes, including animal organ development; muscle cell fate determination; and ureteric peristalsis. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in vertebral anomalies and variable endocrine and T-cell dysfunction. Orthologous to human TBX2 (T-box transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Tbx2 Products(1)

mRNA	Protein	Name
NM_009324.2	NP_033350.2	T-box transcription factor TBX2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15843407	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15843407	MGI
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	33795231	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9710594	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	26486273	MGI
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	33795231	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12023302	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	23117660	MGI
involved in aorta morphogenesis	IMP IMP: Inferred from mutant phenotype	15459098	MGI
involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	33795231	MGI
involved in atrioventricular canal development	IGI IGI: Inferred from genetic interaction	22130515	MGI
involved in atrioventricular canal development	IMP IMP: Inferred from mutant phenotype	15459098	MGI
involved in atrioventricular canal morphogenesis	IGI IGI: Inferred from genetic interaction	22130515	MGI
involved in cardiac muscle cell myoblast differentiation	IDA IDA: Inferred from direct assay	15459098	MGI
acts upstream of or within cardiac muscle tissue development	IMP IMP: Inferred from mutant phenotype	15459098	MGI
acts upstream of or within cellular senescence	IDA IDA: Inferred from direct assay	11748239	MGI
involved in cochlea morphogenesis	IMP IMP: Inferred from mutant phenotype	33795231	MGI
acts upstream of or within developmental growth involved in morphogenesis	IMP IMP: Inferred from mutant phenotype	19769959	MGI
involved in embryonic camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	15459098	MGI
involved in embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	15459098	MGI
involved in endocardial cushion morphogenesis	IMP IMP: Inferred from mutant phenotype	15459098	MGI
involved in epithelial tube branching involved in lung morphogenesis	IGI IGI: Inferred from genetic interaction	27720610	MGI
involved in fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	33795231	MGI
acts upstream of or within heart morphogenesis	IMP IMP: Inferred from mutant phenotype	15459098	MGI
acts upstream of or within mammary placode formation	IGI IGI: Inferred from genetic interaction	16222716	MGI
involved in melanocyte proliferation	IMP IMP: Inferred from mutant phenotype	26486273	MGI
involved in mesenchymal cell proliferation involved in lung development	IMP IMP: Inferred from mutant phenotype	27720610	MGI
acts upstream of or within muscle cell fate determination	IMP IMP: Inferred from mutant phenotype	15459098	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11748239	MGI
involved in negative regulation of cardiac chamber formation	IMP IMP: Inferred from mutant phenotype	15042700	MGI
involved in negative regulation of heart looping	IMP IMP: Inferred from mutant phenotype	15042700	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12023302	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9710594	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	18285513	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	26971330	MGI
involved in neurogenesis	IMP IMP: Inferred from mutant phenotype	33795231	MGI
involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	15042700	MGI
involved in outflow tract septum morphogenesis	IMP IMP: Inferred from mutant phenotype	15459098	MGI
involved in pharyngeal system development	IMP IMP: Inferred from mutant phenotype	15459098	MGI
acts upstream of negative effect pigment metabolic process involved in pigmentation	IMP IMP: Inferred from mutant phenotype	26971330	MGI
involved in positive regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	15042700	MGI
involved in positive regulation of cell cycle G1/S phase transition	IMP IMP: Inferred from mutant phenotype	26486273	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22186728	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	11867218	MGI
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15459098	MGI
involved in response to retinoic acid	IDA IDA: Inferred from direct assay	22186728	MGI
acts upstream of or within roof of mouth development	IGI IGI: Inferred from genetic interaction	19769959	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	19769959	MGI
acts upstream of or within smooth muscle cell differentiation	IGI IGI: Inferred from genetic interaction	30478225	MGI
acts upstream of or within ureteric peristalsis	IGI IGI: Inferred from genetic interaction	30478225	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18025091	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15042700	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	12023302	MGI
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	18285513	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

T-box transcription factor TBX2

T-box protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14275	TBX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22339	Tbx2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28861	Tbx2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tbx2	NCBI	NCBI:6909

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