2. Gene
  3. Tank - TRAF family member-associated Nf-kappa B activator Gene

Tank - TRAF family member-associated Nf-kappa B activator Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as I-TRAF; E430026L09Rik

Gene ID: 21353 | Gene type: protein coding

About Tank

Summary

Predicted to enable Deubiquitinase activator activity and ubiquitin protein Ligase binding activity. Predicted to contribute to thiol-dependent Deubiquitinase. Acts upstream of or within I-kappaB kinase/NF-kappaB signaling. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human TANK (TRAF family member associated NFKB activator). [provided by Alliance of Genome Resources, Apr 2022]

Tank Products(7)

mRNA Protein Name
NM_001164071.1 NP_001157543.1 TRAF family member-associated NF-kappa-B activator isoform 1
NM_001164072.1 NP_001157544.1 TRAF family member-associated NF-kappa-B activator isoform 2
NM_001355267.1 NP_001342196.1 TRAF family member-associated NF-kappa-B activator isoform 1
NM_001355268.1 NP_001342197.1 TRAF family member-associated NF-kappa-B activator isoform 4
NM_001374667.1 NP_001361596.1 TRAF family member-associated NF-kappa-B activator isoform 5
NM_001378922.1 NP_001365851.1 TRAF family member-associated NF-kappa-B activator isoform 6
NM_011529.2 NP_035659.1 TRAF family member-associated NF-kappa-B activator isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables molecular function inhibitor activity IDA
IDA: Inferred from direct assay
8710854 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10581243 MGI
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of tumor necrosis factor-mediated signaling pathway IDA
IDA: Inferred from direct assay
8710854 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TRAF family member-associated NF-kappa-B activator

TRAF-interacting protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-111941 GSK8612 Inhibitor 99.62% Unkown
HY-152237 TBK1-IN-1 Inhibitor 99.63% Unkown
HY-112557 PROTAC TBK1 degrader-2 Inhibitor 98.20% Unkown
HY-117700 TNKS-IN-2 Inhibitor / Unkown
HY-RS14197 TANK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18372 Tank Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24851 Tank Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tank NCBI NCBI:10010