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  2. TANK - TRAF family member associated NFKB activator Gene

TANK - TRAF family member associated NFKB activator Gene

Homo sapiens

Also known as ITRAF; TRAF2; I-TRAF

Gene ID: 10010 | Gene type: protein coding

About TANK

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:161,136,963-161,236,230 (from NCBI)

This gene has 23 transcripts (splice variants) and 187 orthologues. Ubiquitous expression in appendix (RPKM 16.5), lymph node (RPKM 16.3) and 25 other tissues.

Summary

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

TANK Products(3)

mRNA Protein Name
NM_001199135.3 NP_001186064.1 TRAF family member-associated NF-kappa-B activator isoform a
NM_004180.3 NP_004171.2 TRAF family member-associated NF-kappa-B activator isoform a
NM_133484.2 NP_597841.1 TRAF family member-associated NF-kappa-B activator isoform b
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
contributes to cysteine-type deubiquitinase activity IMP
IMP: Inferred from mutant phenotype
25861989 GOA
enables deubiquitinase activator activity IMP
IMP: Inferred from mutant phenotype
25861989 GOA
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
21931631 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12005438 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
11279055 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
25861989 GOA
involved in cellular response to interleukin-1 IMP
IMP: Inferred from mutant phenotype
25861989 GOA
involved in cellular response to ionizing radiation IMP
IMP: Inferred from mutant phenotype
25861989 GOA
involved in cellular response to tumor necrosis factor IMP
IMP: Inferred from mutant phenotype
25861989 GOA
involved in negative regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
25861989 GOA
involved in positive regulation of protein deubiquitination IMP
IMP: Inferred from mutant phenotype
25861989 GOA
involved in positive regulation of type I interferon production IDA
IDA: Inferred from direct assay
21931631 GOA
involved in positive regulation of ubiquitin-specific protease activity IMP
IMP: Inferred from mutant phenotype
25861989 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
21931631 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
25861989 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TANK Protein Structure

TBD

TBD: TBD domain (130 - 186)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 425 a.a.
Protein Preferred Names Protein Names

TRAF family member-associated NF-kappa-B activator

TRAF-interacting protein

Related Diseases

Diseases Alias
Nipah Virus Encephalitis

Equine Morbillivirus

Immunodeficiency 33

IMD33

X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Ikbkg Deficiency

X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Nemo Deficiency

X-Linked Msmd Due To Ikbkg Deficiency

X-Linked Msmd Due To Nemo Deficiency

Invasive Pneumococcal Disease, Recurrent Isolated, 2

Invasive Pneumococcal Disease, Recurrent Isolated, 2, Formerly

Ipd2, Formerly

Nf-Kappa B Essential Modulator Deficiency

Familial X-Linked 1 Atypical Mycobacteriosis

Nemo Deficiency Syndrome

Amcbx1

Familial, X-Linked, Atypical Mycobacteriosis 1

Ipd2

Recurrent Isolated Invasive Pneumococcal Disease 2

X-Linked Disseminated Atypical Mycobacterial Infection Type 1

X-Linked Immunodeficiency 33, Mycobacteriosis

X-Linked Susceptibility To Mycobacterial Disease Type 1

Invasive Pneumococcal Disease, Recurrent Isolated, Type 2

Atypical Mycobacteriosis, Familial, X-Linked 1

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 4

FTDALS4

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-4

Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis, Type 4

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TANK RGD RGD:628859
Felis catus TANK VGNC VGNC:65952
Mus musculus TANK MGD MGI:107676
Bos taurus TANK VGNC VGNC:35594
Macaca mulatta TANK VGNC VGNC:78097
Canis familiaris TANK VGNC VGNC:47101
Others TANK NCBI