Abcc9 - ATP-binding cassette, sub-family C (CFTR/MRP), member 9 Gene

Mus musculus

Also known as Sur2; SUR2A; SUR2B

Gene ID: 20928 | Gene type: protein coding

About Abcc9

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extrapancreatic ATP-sensitive potassium channels. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Abcc9 Products(8)

mRNA	Protein	Name
NM_001044720.2	NP_001038185.1	ATP-binding cassette sub-family C member 9 isoform d
NM_001310143.2	NP_001297072.1	ATP-binding cassette sub-family C member 9 isoform e
NM_001410414.1	NP_001397343.1	ATP-binding cassette sub-family C member 9 isoform f
NM_001410415.1	NP_001397344.1	ATP-binding cassette sub-family C member 9 isoform g
NM_001410416.1	NP_001397345.1	ATP-binding cassette sub-family C member 9 isoform h
NM_011511.3	NP_035641.1	ATP-binding cassette sub-family C member 9 isoform a
NM_021041.3	NP_066378.1	ATP-binding cassette sub-family C member 9 isoform b
NM_021042.3	NP_066379.2	ATP-binding cassette sub-family C member 9 isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to potassium channel activity	IMP IMP: Inferred from mutant phenotype	20656890	MGI
enables potassium channel activity	IMP IMP: Inferred from mutant phenotype	16456098	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18001767	MGI
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	11934987	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within ATP metabolic process	IDA IDA: Inferred from direct assay	20123112	MGI
acts upstream of or within MAPK cascade	IMP IMP: Inferred from mutant phenotype	11934987	MGI
acts upstream of or within action potential	IDA IDA: Inferred from direct assay	24037327	MGI
acts upstream of or within action potential	IMP IMP: Inferred from mutant phenotype	24037327	MGI
acts upstream of or within blood circulation	IMP IMP: Inferred from mutant phenotype	24936167	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	30089727	MGI
acts upstream of or within blood vessel diameter maintenance	IMP IMP: Inferred from mutant phenotype	19675276	MGI
acts upstream of or within positive effect cardiac muscle cell contraction	IMP IMP: Inferred from mutant phenotype	31575858	MGI
acts upstream of or within cellular respiration	IMP IMP: Inferred from mutant phenotype	24648545	MGI
acts upstream of or within cellular response to ATP	IDA IDA: Inferred from direct assay	24037327	MGI
acts upstream of or within cellular response to ATP	IMP IMP: Inferred from mutant phenotype	20935152	MGI
acts upstream of or within cellular response to calcium ion	IDA IDA: Inferred from direct assay	24037327	MGI
acts upstream of or within cellular response to calcium ion	IMP IMP: Inferred from mutant phenotype	20935152	MGI
acts upstream of or within cellular response to chemical stress	IDA IDA: Inferred from direct assay	20123112	MGI
acts upstream of or within cellular response to potassium ion	IMP IMP: Inferred from mutant phenotype	20935152	MGI
acts upstream of or within cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	24037327	MGI
acts upstream of or within cellular response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	24037327	MGI
acts upstream of or within circulatory system development	IMP IMP: Inferred from mutant phenotype	30089727	MGI
acts upstream of or within coronary vasculature development	IGI IGI: Inferred from genetic interaction	31821173	MGI
acts upstream of or within cytokine production	IGI IGI: Inferred from genetic interaction	19166858	MGI
acts upstream of or within fatty acid oxidation	IMP IMP: Inferred from mutant phenotype	24648545	MGI
acts upstream of or within fibroblast proliferation	IGI IGI: Inferred from genetic interaction	19166858	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	11934987	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	19675276	MGI
acts upstream of or within heart morphogenesis	IGI IGI: Inferred from genetic interaction	31821173	MGI
acts upstream of or within heart morphogenesis	IMP IMP: Inferred from mutant phenotype	30089727	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	24648545	MGI
acts upstream of or within negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	20123112	MGI
acts upstream of or within negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	31575858	MGI
acts upstream of or within oxygen metabolic process	IMP IMP: Inferred from mutant phenotype	24648545	MGI
acts upstream of or within potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	20123112	MGI
acts upstream of or within reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	20935152	MGI
acts upstream of or within regulation of blood pressure	IGI IGI: Inferred from genetic interaction	31821173	MGI
acts upstream of or within regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	19675276	MGI
acts upstream of or within regulation of cation channel activity	IGI IGI: Inferred from genetic interaction	31821173	MGI
acts upstream of or within regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	20935152	MGI
acts upstream of or within regulation of potassium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	18001767	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	11934987	MGI
acts upstream of or within regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	IMP IMP: Inferred from mutant phenotype	31575858	MGI
acts upstream of or within response to ATP	IMP IMP: Inferred from mutant phenotype	30089727	MGI
acts upstream of or within response to activity	IMP IMP: Inferred from mutant phenotype	19675276	MGI
acts upstream of or within response to decreased oxygen levels	IMP IMP: Inferred from mutant phenotype	20935152	MGI
acts upstream of or within response to estrogen	IDA IDA: Inferred from direct assay	24936167	MGI
acts upstream of or within response to estrogen	IMP IMP: Inferred from mutant phenotype	24936167	MGI
acts upstream of or within response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	24648545	MGI
acts upstream of or within response to hydrogen sulfide	IMP IMP: Inferred from mutant phenotype	21421823	MGI
acts upstream of or within response to hypoxia	IDA IDA: Inferred from direct assay	20123112	MGI
acts upstream of or within response to hypoxia	IMP IMP: Inferred from mutant phenotype	20935152	MGI
acts upstream of or within response to oxygen levels	IMP IMP: Inferred from mutant phenotype	24936167	MGI
acts upstream of or within response to peptide	IMP IMP: Inferred from mutant phenotype	11934987	MGI
acts upstream of or within response to potassium ion	IMP IMP: Inferred from mutant phenotype	18001767	MGI
acts upstream of or within response to stress	IMP IMP: Inferred from mutant phenotype	19675276	MGI
acts upstream of or within response to xenobiotic stimulus	IGI IGI: Inferred from genetic interaction	19166858	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	11934987	MGI
acts upstream of or within skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	19675276	MGI
acts upstream of or within vascular process in circulatory system	IMP IMP: Inferred from mutant phenotype	16456098	MGI
acts upstream of or within vasodilation	IMP IMP: Inferred from mutant phenotype	21421823	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	18434629	MGI
is active in mitochondrion	IDA IDA: Inferred from direct assay	19797704	MGI
is active in mitochondrion	IMP IMP: Inferred from mutant phenotype	19797704	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	24037327	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16085792	MGI
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	11934987	MGI
is active in sarcolemma	IDA IDA: Inferred from direct assay	18001767	MGI
located in sarcomere	IDA IDA: Inferred from direct assay	16085792	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ATP-binding cassette sub-family C member 9

ATP-binding cassette transporter sub-family C member 9	sulfonylurea receptor 2
sulfonylurea-binding protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00067	ABCC9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22364	Abcc9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Abcc9	NCBI	NCBI:10060

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