2. Gene
  3. Cblb - Casitas B-lineage lymphoma b Gene

Cblb - Casitas B-lineage lymphoma b Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cbl-b

Gene ID: 208650 | Gene type: protein coding

About Cblb

Summary

Predicted to enable SH3 domain binding activity; receptor tyrosine kinase binding activity; and ubiquitin protein Ligase activity. Involved in regulation of platelet-derived growth factor receptor-alpha signaling pathway. Acts upstream of or within several processes, including T cell receptor signaling pathway; positive regulation of T cell anergy; and positive regulation of protein metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in membrane raft and plasma membrane. Is expressed in brain; extrinsic ocular muscle; and incisor. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and type 1 diabetes mellitus. Orthologous to human CBLB (Cbl proto-oncogene B). [provided by Alliance of Genome Resources, Apr 2022]

Cblb Products(1)

mRNA Protein Name
NM_001033238.1 NP_001028410.1 E3 ubiquitin-protein ligase CBL-B
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12697763 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of CD4-positive, alpha-beta T cell proliferation IMP
IMP: Inferred from mutant phenotype
14973438 MGI
acts upstream of or within T cell activation IMP
IMP: Inferred from mutant phenotype
11070165 MGI
acts upstream of T cell anergy IMP
IMP: Inferred from mutant phenotype
14973438 MGI
acts upstream of or within T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12697763 MGI
acts upstream of or within immune response IMP
IMP: Inferred from mutant phenotype
11070165 MGI
acts upstream of or within intracellular signal transduction IMP
IMP: Inferred from mutant phenotype
11070165 MGI
acts upstream of or within negative regulation of CD4-positive, alpha-beta T cell proliferation IMP
IMP: Inferred from mutant phenotype
14973438 MGI
acts upstream of or within negative regulation of T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
14738763 MGI
acts upstream of or within peptidyl-amino acid modification IDA
IDA: Inferred from direct assay
12697763 MGI
acts upstream of or within positive regulation of T cell anergy IMP
IMP: Inferred from mutant phenotype
14973438 MGI
acts upstream of or within positive regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
14973438 MGI
acts upstream of or within positive regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
12697763 MGI
acts upstream of protein catabolic process IMP
IMP: Inferred from mutant phenotype
14973438 MGI
acts upstream of or within regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
12697763 MGI
acts upstream of or within regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
12697763 MGI
involved in regulation of platelet-derived growth factor receptor-alpha signaling pathway IMP
IMP: Inferred from mutant phenotype
29237719 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: Inferred from direct assay
32606037 MGI
acts upstream of or within regulation of protein binding IMP
IMP: Inferred from mutant phenotype
12697763 MGI
involved in regulation protein catabolic process at postsynapse IDA
IDA: Inferred from direct assay
32606037 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
32606037 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
32606037 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase CBL-B

RING-type E3 ubiquitin transferase CBL-B

SH3-binding protein CBL-B

casitas B-lineage lymphoma proto-oncogene b

signal transduction protein CBL-B

Cblb Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Cblb Q3TTA7 Cd5 Mus musculus P13379
Affinity Chrom
27474268
Intra
Cblb Q3TTA7 Cd5 Mus musculus P13379
Anti Bait CoIP
27474268
Intra
Cblb Q3TTA7 Ticam1 Mus musculus Q80UF7
Anti Tag CoIP
20639876
Intra
Cblb Q3TTA7 Ticam1 Mus musculus Q80UF7
Anti Bait CoIP
20639876
Intra
Cblb Q3TTA7 Myd88 Mus musculus P22366
Anti Bait CoIP
20639876
Intra
Cblb Q3TTA7 Myd88 Mus musculus P22366
Anti Tag CoIP
20639876
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (24)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-141432 NX-1607 Inhibitor 99.87% Unkown
HY-136339 Cbl-b-IN-1 Inhibitor 99.66% Unkown
HY-141431 Cbl-b-IN-2 Inhibitor / Unkown
HY-155120 Cbl-b-IN-5 Inhibitor 99.61% Unkown
HY-156768 Cbl-b-IN-12 Inhibitor / Unkown
HY-155477 Cbl-b-IN-15 Inhibitor / Unkown
HY-156762 Cbl-b-IN-6 Inhibitor / Unkown
HY-156763 Cbl-b-IN-7 Inhibitor / Unkown
HY-156764 Cbl-b-IN-8 Inhibitor / Unkown
HY-156765 Cbl-b-IN-9 Inhibitor / Unkown
HY-156766 Cbl-b-IN-10 Inhibitor / Unkown
HY-156767 Cbl-b-IN-11 Inhibitor / Unkown
HY-156769 Cbl-b-IN-13 Inhibitor / Unkown
HY-158171 Cbl-b-IN-17 Inhibitor / Unkown
HY-158173 Cbl-b-IN-19 Inhibitor / Unkown
HY-159608 PROTAC Cbl-b-IN-1 / Unkown
HY-161977 Cbl-b-IN-26 Inhibitor / Unkown
HY-163194 Cbl-b-IN-16 Inhibitor / Unkown
HY-169005 Cbl-b-IN-27 Inhibitor / Unkown
HY-173311 Cbl-b-IN-28 / Unkown
HY-RS01997 CBLB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-141432G NX-1607 (GMP) Inhibitor / Unkown
HY-RS17948 Cblb Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24419 Cblb Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P991076 Entolimod Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cblb NCBI NCBI:868