Smarca4 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Gene

Mus musculus

Also known as Brg1; BAF190A; SW1/SNF; HP1-BP72; SNF2beta; b2b692Clo; b2b508.1Clo

Gene ID: 20586 | Gene type: protein coding

About Smarca4

Summary

Enables several functions, including ATP hydrolysis activity; DNA Polymerase binding activity; and nucleic acid binding activity. Involved in nervous system development; positive regulation of Wnt signaling pathway; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within several processes, including animal organ development; blastocyst development; and circulatory system development. Located in euchromatin; heterochromatin; and perichromatin fibrils. Part of SWI/SNF complex; nBAF complex; and npBAF complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study breast Cancer. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 4; hepatocellular carcinoma; lung non-small cell carcinoma; and rhabdoid Cancer. Orthologous to human SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4). [provided by Alliance of Genome Resources, Apr 2022]

Smarca4 Products(4)

mRNA	Protein	Name
NM_001174078.1	NP_001167549.1	transcription activator BRG1 isoform 1
NM_001174079.1	NP_001167550.1	transcription activator BRG1 isoform 3
NM_001357764.1	NP_001344693.1	transcription activator BRG1 isoform 4
NM_011417.3	NP_035547.2	transcription activator BRG1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP hydrolysis activity	IMP IMP: Inferred from mutant phenotype	22513373	MGI
enables ATP-dependent chromatin remodeler activity	IDA IDA: Inferred from direct assay	34910916	MGI
enables DNA polymerase binding	IPI IPI: Inferred from physical interaction	19571879	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23319608	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20176728	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	10318760	MGI
enables lncRNA binding	IPI IPI: Inferred from physical interaction	25119045	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7923370	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	15767674	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within aorta development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within aortic smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	19342595	MGI
acts upstream of or within blastocyst growth	IMP IMP: Inferred from mutant phenotype	11163203	MGI
acts upstream of or within blastocyst hatching	IMP IMP: Inferred from mutant phenotype	11163203	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	23319608	MGI
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	16287714	MGI
acts upstream of or within chromatin remodeling	IMP IMP: Inferred from mutant phenotype	16287714	MGI
acts upstream of or within coronary vasculature development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within definitive erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	16287714	MGI
acts upstream of or within embryonic hindlimb morphogenesis	IMP IMP: Inferred from mutant phenotype	16192310	MGI
acts upstream of or within embryonic organ morphogenesis	IMP IMP: Inferred from mutant phenotype	16287714	MGI
acts upstream of or within epidermis morphogenesis	IMP IMP: Inferred from mutant phenotype	16192310	MGI
acts upstream of or within extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	18267097	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	16330018	MGI
acts upstream of or within negative effect gene expression	IDA IDA: Inferred from direct assay	25119045	MGI
acts upstream of or within glial cell fate determination	IMP IMP: Inferred from mutant phenotype	16330018	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	18267097	MGI
acts upstream of or within heart trabecula formation	IGI IGI: Inferred from genetic interaction	18267097	MGI
acts upstream of or within hindbrain development	IMP IMP: Inferred from mutant phenotype	16330018	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	16287714	MGI
acts upstream of or within keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	16192310	MGI
acts upstream of or within lens fiber cell development	IMP IMP: Inferred from mutant phenotype	21118511	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	16287714	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	23319608	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18267097	MGI
involved in nervous system development	IMP IMP: Inferred from mutant phenotype	17640523	MGI
acts upstream of or within neurogenesis	IDA IDA: Inferred from direct assay	22513373	MGI
acts upstream of or within outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	23319608	MGI
acts upstream of or within pharyngeal arch artery morphogenesis	IMP IMP: Inferred from mutant phenotype	23319608	MGI
acts upstream of or within positive regulation of DNA binding	IGI IGI: Inferred from genetic interaction	19342595	MGI
involved in positive regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	19571879	MGI
acts upstream of or within positive regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	23319608	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	23319608	MGI
involved in positive regulation of cold-induced thermogenesis	IDA IDA: Inferred from direct assay	34910916	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22162999	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19342595	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16287714	MGI
acts upstream of or within primitive erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	16287714	MGI
acts upstream of or within regulation of cell migration	IMP IMP: Inferred from mutant phenotype	23319608	MGI
acts upstream of or within stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	20176728	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19342595	MGI
involved in transcription initiation-coupled chromatin remodeling	IDA IDA: Inferred from direct assay	34910916	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	18267097	MGI
acts upstream of or within ventricular septum development	IMP IMP: Inferred from mutant phenotype	25807483	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of SWI/SNF complex	IDA IDA: Inferred from direct assay	16287714	MGI
part of SWI/SNF superfamily-type complex	IDA IDA: Inferred from direct assay	12368262	MGI
located in euchromatin	IDA IDA: Inferred from direct assay	10318760	MGI
located in male germ cell nucleus	IDA IDA: Inferred from direct assay	16787967	MGI
part of nBAF complex	IDA IDA: Inferred from direct assay	17640523	MGI
part of npBAF complex	IDA IDA: Inferred from direct assay	17640523	MGI
NOT located in nucleolus	IDA IDA: Inferred from direct assay	10318760	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	34910916	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9603422	MGI
located in perichromatin fibrils	IDA IDA: Inferred from direct assay	10318760	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription activator BRG1

ATP-dependent helicase SMARCA4	BRG1-associated factor 190A
SNF2-beta	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
protein brahma homolog 1

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-144835	Camibirstat	Inhibitor	99.06%	Phase 1

Pre-clinical Phase

Bioactive Molecules (62)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119374	BRM/BRG1 ATP Inhibitor-1	Inhibitor	99.72%	Unkown
HY-145388	AU-15330		99.89%	Unkown
HY-128359	ACBI1		99.92%	Unkown
HY-144896	FHT-1015	Inhibitor	98.41%	Unkown
HY-163410	AU-24118	Degrader	99.10%	Unkown
HY-149026	GNE-064	Inhibitor	99.65%	Unkown
HY-125905	VH032-cyclopropane-F		99.92%	Unkown
HY-153361	YD23		98.80%	Unkown
HY-144897	FHT-1204	Inhibitor	99.81%	Unkown
HY-149458	FHT-2344	Inhibitor	99.67%	Unkown
HY-156568B	SMD-3040 formate	Degrader	99.78%	Unkown
HY-156568	SMD-3040	Degrader	99.91%	Unkown
HY-156568A	SMD-3040 TFA	Degrader	99.90%	Unkown
HY-159607	PRT3789	Degrader	/	Unkown
HY-122573	Bromodomain inhibitor-13	Inhibitor	/	Unkown
HY-122645	SMARCA2-IN-4	Inhibitor	/	Unkown
HY-144720	BRG1-IN-1		/	Unkown
HY-153425	PROTAC SMARCA2 degrader-2		/	Unkown
HY-159449	PROTAC SMARCA2 degrader-5	Degrader	/	Unkown
HY-159451	PROTAC SMARCA2 degrader-7	Inhibitor	/	Unkown
HY-159452	PROTAC SMARCA2/4-degrader-1		/	Unkown
HY-159453	PROTAC SMARCA2/4-degrader-2		/	Unkown
HY-159455	PROTAC SMARCA2/4-degrader-4	Degrader	/	Unkown
HY-159456	PROTAC SMARCA2/4-degrader-5	Degrader	/	Unkown
HY-159458	PROTAC SMARCA2/4-degrader-7		/	Unkown
HY-159459	PROTAC SMARCA2/4-degrader-32		/	Unkown
HY-159460	PROTAC SMARCA2/4-degrader-8	Inhibitor	/	Unkown
HY-159461	PROTAC SMARCA2/4-degrader-9	Degrader	/	Unkown
HY-161884	SMARCA2/4-IN-1	Inhibitor	/	Unkown
HY-161885	SMARCA2-IN-6	Inhibitor	/	Unkown
HY-161887	SMARCA2-IN-8	Inhibitor	/	Unkown
HY-162741	PROTAC SMARCA2/4-degrader-33		/	Unkown
HY-162743	PROTAC SMARCA2/4-degrader-29	Degrader	/	Unkown
HY-162744	PROTAC SMARCA2/4-degrader-31	Degrader	/	Unkown
HY-162748	PROTAC SMARCA2/4-degrader-30	Degrader	/	Unkown
HY-162815	PROTAC SMARCA2/4-degrader-26		/	Unkown
HY-162834	PROTAC SMARCA2/4-degrader-27	Degrader	/	Unkown
HY-162835	PROTAC SMARCA2/4-degrader-28	Degrader	/	Unkown
HY-163868	PROTAC SMARCA2/4-degrader-15	Degrader	/	Unkown
HY-163869	PROTAC SMARCA2/4-degrader-16		/	Unkown
HY-163870	PROTAC SMARCA2/4-degrader-17	Degrader	/	Unkown
HY-163871	PROTAC SMARCA2/4-degrader-18	Degrader	/	Unkown
HY-163872	PROTAC SMARCA2/4-degrader-10	Degrader	/	Unkown
HY-163873	PROTAC SMARCA2/4-degrader-20	Degrader	/	Unkown
HY-163875	PROTAC SMARCA2/4-degrader-22		/	Unkown
HY-163876	PROTAC SMARCA2/4-degrader-23		/	Unkown
HY-163877	PROTAC SMARCA2/4-degrader-19	Degrader	/	Unkown
HY-168215	YDR1	Degrader	/	Unkown
HY-168221	YD54		/	Unkown
HY-169270	PROTAC SMARCA2 degrader-19	Degrader	/	Unkown
HY-169272	PROTAC SMARCA2 degrader-21	Degrader	/	Unkown
HY-169275	PROTAC SMARCA2 degrader-24	Degrader	/	Unkown
HY-169278	PROTAC SMARCA2 degrader-26	Degrader	/	Unkown
HY-169279	PROTAC SMARCA2/4-degrader-34	Degrader	/	Unkown
HY-170347	PROTAC SMARCA2/4 degrader-36	Degrader	/	Unkown
HY-170824	SMD-3236	Degrader	/	Unkown
HY-170828	SMD-1087	Degrader	/	Unkown
HY-171774	PBRM1/SMARCA2,4-ligand-1		/	Unkown
HY-174237	PBRM1/SMARCA2,4 binder-1		/	Unkown
HY-RS13405	SMARCA4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16803	Smarca4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23244	Smarca4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Smarca4	NCBI	NCBI:6597

Name
Email *

	Sorry, but the email address you supplied was invalid.