Slc22a1 - solute carrier family 22 (organic cation transporter), member 1 Gene

Mus musculus

Also known as Lx1; Oct1; Orct; Orct1

Gene ID: 20517 | Gene type: protein coding

About Slc22a1

Summary

Enables several functions, including pyrimidine nucleoside transmembrane transporter activity; toxin transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in toxin transport and xenobiotic transport. Acts upstream of or within cation transport. Located in apical plasma membrane. Is expressed in several structures, including adrenal gland; liver; mammary gland; metanephros; and nasal cavity mucosa. Orthologous to human SLC22A1 (solute carrier family 22 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc22a1 Products(1)

mRNA	Protein	Name
NM_009202.5	NP_033228.2	solute carrier family 22 member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables (R)-carnitine transmembrane transporter activity	IDA IDA: Inferred from direct assay	28942964	MGI
enables monoamine transmembrane transporter activity	IDA IDA: Inferred from direct assay	24961373	MGI
enables neurotransmitter transmembrane transporter activity	IDA IDA: Inferred from direct assay	24961373	MGI
enables organic cation transmembrane transporter activity	IDA IDA: Inferred from direct assay	12176030	MGI
enables pyrimidine nucleoside transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	20477935	MGI
enables quaternary ammonium group transmembrane transporter activity	IDA IDA: Inferred from direct assay	35469921	MGI
enables spermidine transmembrane transporter activity	IDA IDA: Inferred from direct assay	23458604	MGI
enables thiamine transmembrane transporter activity	IDA IDA: Inferred from direct assay	24961373	MGI
enables toxin transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	20477935	MGI
enables xenobiotic transmembrane transporter activity	IDA IDA: Inferred from direct assay	11463829	MGI
enables xenobiotic transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	20477935	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in (R)-carnitine transmembrane transport	IDA IDA: Inferred from direct assay	28942964	MGI
involved in acyl carnitine transmembrane transport	IDA IDA: Inferred from direct assay	28942964	MGI
involved in cellular detoxification	IMP IMP: Inferred from mutant phenotype	20477935	MGI
involved in dopamine transport	IDA IDA: Inferred from direct assay	35469921	MGI
involved in epinephrine transport	IDA IDA: Inferred from direct assay	35469921	MGI
involved in monoamine transport	IDA IDA: Inferred from direct assay	35469921	MGI
acts upstream of or within monoatomic cation transport	IDA IDA: Inferred from direct assay	12176030	MGI
involved in norepinephrine transport	IDA IDA: Inferred from direct assay	35469921	MGI
involved in serotonin transport	IDA IDA: Inferred from direct assay	24961373	MGI
involved in spermidine transport	IDA IDA: Inferred from direct assay	23458604	MGI
involved in thiamine transmembrane transport	IDA IDA: Inferred from direct assay	24961373	MGI
involved in xenobiotic transport	IDA IDA: Inferred from direct assay	11463829	MGI
involved in xenobiotic transport	IMP IMP: Inferred from mutant phenotype	20477935	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	20477935	MGI
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	28942964	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

solute carrier family 22 member 1

mOCT1	organic cation transporter 1
solute carrier family 22, member 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13061	SLC22A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19841	Slc22a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26339	Slc22a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc22a1	NCBI	NCBI:6580

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