Six2 - sine oculis-related homeobox 2 Gene

Mus musculus

Gene ID: 20472 | Gene type: protein coding

About Six2

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including embryonic morphogenesis; kidney development; and positive regulation of chondrocyte proliferation. Acts upstream of or within several processes, including animal organ development; condensed mesenchymal cell proliferation; and protein import into nucleus. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human SIX2 (SIX homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Six2 Products(1)

mRNA	Protein	Name
NM_011380.2	NP_035510.1	homeobox protein SIX2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15327782	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15327782	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15327782	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11734542	MGI
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	17785448	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8814301	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	22902740	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in anterior/posterior axis specification	IDA IDA: Inferred from direct assay	18321982	MGI
acts upstream of or within cell population proliferation	IMP IMP: Inferred from mutant phenotype	20515681	MGI
acts upstream of or within chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	20515681	MGI
acts upstream of or within condensed mesenchymal cell proliferation	IGI IGI: Inferred from genetic interaction	26116661	MGI
acts upstream of or within embryonic cranial skeleton morphogenesis	IMP IMP: Inferred from mutant phenotype	20515681	MGI
involved in embryonic digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	19660448	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IGI IGI: Inferred from genetic interaction	15634706	MGI
acts upstream of epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	17036046	MGI
involved in kidney development	IMP IMP: Inferred from mutant phenotype	17036046	MGI
involved in mesenchymal cell differentiation involved in kidney development	IMP IMP: Inferred from mutant phenotype	17036046	MGI
involved in mesenchymal stem cell maintenance involved in nephron morphogenesis	IDA IDA: Inferred from direct assay	22902740	MGI
involved in mesenchymal stem cell maintenance involved in nephron morphogenesis	IMP IMP: Inferred from mutant phenotype	18682239	MGI
involved in mesenchymal stem cell proliferation	IMP IMP: Inferred from mutant phenotype	21350016	MGI
involved in mesenchymal to epithelial transition involved in metanephros morphogenesis	IEP IEP: Inferred from expression pattern	10322633	MGI
involved in mesodermal cell fate specification	IDA IDA: Inferred from direct assay	17785448	MGI
acts upstream of or within metanephros development	IMP IMP: Inferred from mutant phenotype	17036046	MGI
acts upstream of or within middle ear morphogenesis	IGI IGI: Inferred from genetic interaction	15634706	MGI
acts upstream of or within negative regulation of epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	17036046	MGI
involved in nephron development	IMP IMP: Inferred from mutant phenotype	18682239	MGI
involved in nephron morphogenesis	IMP IMP: Inferred from mutant phenotype	17036046	MGI
involved in positive regulation of chondrocyte proliferation	IMP IMP: Inferred from mutant phenotype	20515681	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15327782	MGI
acts upstream of or within protein import into nucleus	IDA IDA: Inferred from direct assay	16024294	MGI
involved in regulation of branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	17036046	MGI
involved in regulation of chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	20515681	MGI
involved in regulation of ossification	IMP IMP: Inferred from mutant phenotype	20515681	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	8814301	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein SIX2

sine oculis homeobox homolog 2

sine oculis-related homeobox 2 homolog

Six2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Six2	Q62232	Eya1	Mus musculus	P97767	Pull Down	11734542

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12959	SIX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19955	Six2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26457	Six2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Six2	NCBI	NCBI:10736

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