2. Gene
  3. Sim1 - single-minded family bHLH transcription factor 1 Gene

Sim1 - single-minded family bHLH transcription factor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as mSIM1; bHLHe14

Gene ID: 20464 | Gene type: protein coding

About Sim1

Summary

Enables protein heterodimerization activity. Acts upstream of or within regulation of transcription, DNA-templated and ureteric bud development. Located in nucleus. Is expressed in several structures, including central nervous system; limb bud; metanephros; paraxial mesenchyme; and sensory organ. Used to study obesity. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SIM1 (SIM bHLH transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Sim1 Products(1)

mRNA Protein Name
NM_011376.3 NP_035506.2 single-minded homolog 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
9020169 MGI
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
27782878 MGI
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
8927054 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11782478 MGI
involved in ureteric bud development IEP
IEP: Inferred from expression pattern
16545622 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
11782478 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

single-minded homolog 1

single-minded 1

Sim1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Sim1 Q61045 Arnt Mus musculus P53762
Y2H
9020169
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-141438 SIM1 Inhibitor 99.57% Unkown
HY-141438A cis-SIM1 Control / Unkown
HY-RS12922 SIM1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18152 Sim1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sim1 NCBI NCBI:6492