Prrx2 - paired related homeobox 2 Gene

Mus musculus

Also known as S8; Prx2

Gene ID: 20204 | Gene type: protein coding

About Prrx2

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic morphogenesis; positive regulation of mesenchymal cell proliferation; and positive regulation of smoothened signaling pathway. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; embryo mesenchyme; and genitourinary system. Orthologous to human PRRX2 (paired related homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Prrx2 Products(1)

mRNA	Protein	Name
NM_009116.2	NP_033142.2	paired mesoderm homeobox protein 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	12713735	MGI
enables HMG box domain binding	IPI IPI: Inferred from physical interaction	16582099	MGI
enables RNA polymerase II general transcription initiation factor activity	IDA IDA: Inferred from direct assay	32188878	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	12713735	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within artery morphogenesis	IGI IGI: Inferred from genetic interaction	10664157	MGI
acts upstream of or within cartilage development	IGI IGI: Inferred from genetic interaction	9876178	MGI
acts upstream of or within embryonic cranial skeleton morphogenesis	IGI IGI: Inferred from genetic interaction	9729491	MGI
acts upstream of or within embryonic limb morphogenesis	IGI IGI: Inferred from genetic interaction	9729491	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IGI IGI: Inferred from genetic interaction	9729491	MGI
acts upstream of or within inner ear morphogenesis	IGI IGI: Inferred from genetic interaction	9729491	MGI
acts upstream of mesenchymal cell proliferation	IGI IGI: Inferred from genetic interaction	11532916	MGI
acts upstream of or within middle ear morphogenesis	IGI IGI: Inferred from genetic interaction	9729491	MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation	IGI IGI: Inferred from genetic interaction	11532916	MGI
acts upstream of or within positive regulation of smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	11532916	MGI
acts upstream of or within positive regulation of stem cell proliferation	IGI IGI: Inferred from genetic interaction	11532916	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12713735	MGI
acts upstream of smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	11532916	MGI
acts upstream of stem cell proliferation	IGI IGI: Inferred from genetic interaction	11532916	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

paired mesoderm homeobox protein 2

PRX-2	homeo box of paired rule
homeobox protein S8	surface antigen, homeo box of paired rule

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11244	PRRX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22743	Prrx2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29257	Prrx2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prrx2	NCBI	NCBI:51450

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