Ruvbl2 - RuvB-like protein 2 Gene

Mus musculus

Also known as p47; mp47

Gene ID: 20174 | Gene type: protein coding

About Ruvbl2

Summary

Enables several functions, including ATPase binding activity; TFIID-class transcription factor complex binding activity; and adenyl ribonucleotide binding activity. Predicted to be involved in several processes, including box C/D snoRNP assembly; histone acetylation; and positive regulation of nitrogen compound metabolic process. Predicted to act upstream of or within DNA recombination; DNA repair; and chromatin organization. Part of ribonucleoprotein complex. Is expressed in several structures, including axial musculature; branchial arch; limb; sensory organ; and viscerocranium. Orthologous to human RUVBL2 (RuvB like AAA ATPase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ruvbl2 Products(1)

mRNA	Protein	Name
NM_011304.4	NP_035434.1	ruvB-like 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ADP binding	IDA IDA: Inferred from direct assay	17636026	MGI
enables ATP binding	IDA IDA: Inferred from direct assay	17636026	MGI
enables ATPase binding	IPI IPI: Inferred from physical interaction	17636026	MGI
enables TFIID-class transcription factor complex binding	IPI IPI: Inferred from physical interaction	17636026	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17636026	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	17636026	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA repair	IDA IDA: Inferred from direct assay	23979016	MGI
involved in positive regulation of telomere maintenance in response to DNA damage	IMP IMP: Inferred from mutant phenotype	23979016	MGI
involved in regulation of DNA repair	IDA IDA: Inferred from direct assay	23979016	MGI
involved in regulation of embryonic development	IMP IMP: Inferred from mutant phenotype	23979016	MGI
involved in telomere maintenance	IMP IMP: Inferred from mutant phenotype	23979016	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	19299493	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ruvB-like 2

reptin

Ruvbl2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ruvbl2	Q9WTM5	Ruvbl1	Mus musculus	P60122	Y2H Array	20211142

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-146074	RUVBL1/2 ATPase-IN-1	Inhibitor	99.63%	Unkown
HY-RS12355	RUVBL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17670	Ruvbl2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24131	Ruvbl2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ruvbl2	NCBI	NCBI:10856

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