Rs1 - retinoschisis (X-linked, juvenile) 1 (human) Gene

Mus musculus

Also known as Rs1h; Xlrs1; tmgc1

Gene ID: 20147 | Gene type: protein coding

About Rs1

Summary

Enables phosphatidylinositol-3,4-bisphosphate binding activity and phospholipid binding activity. Acts upstream of or within adaptation of rhodopsin mediated signaling and retina layer formation. Located in extracellular region; neuron to neuron synapse; and photoreceptor inner segment. Is extrinsic component of plasma membrane. Used to study X-linked juvenile retinoschisis 1. Human ortholog(s) of this gene implicated in X-linked juvenile retinoschisis 1 and retinoschisis. Orthologous to human RS1 (retinoschisin 1). [provided by Alliance of Genome Resources, Apr 2022]

Rs1 Products(1)

mRNA	Protein	Name
NM_011302.3	NP_035432.3	retinoschisin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables phosphatidylcholine binding	IDA IDA: Inferred from direct assay	17325137	MGI
NOT enables phosphatidylethanolamine binding	IDA IDA: Inferred from direct assay	17325137	MGI
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: Inferred from direct assay	17325137	MGI
enables phosphatidylinositol-3,4-bisphosphate binding	IDA IDA: Inferred from direct assay	17325137	MGI
enables phosphatidylinositol-3,5-bisphosphate binding	IDA IDA: Inferred from direct assay	17325137	MGI
enables phosphatidylinositol-3-phosphate binding	IDA IDA: Inferred from direct assay	17325137	MGI
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	17325137	MGI
enables phosphatidylinositol-4-phosphate binding	IDA IDA: Inferred from direct assay	17325137	MGI
enables phosphatidylinositol-5-phosphate binding	IDA IDA: Inferred from direct assay	17325137	MGI
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	17325137	MGI
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	17804407	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within retina layer formation	IMP IMP: Inferred from mutant phenotype	11983912	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cell surface	IDA IDA: Inferred from direct assay	17804407	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	17325137	MGI
located in extracellular region	IDA IDA: Inferred from direct assay	12853421	MGI
located in neuron to neuron synapse	IDA IDA: Inferred from direct assay	21196491	MGI
located in photoreceptor inner segment	IDA IDA: Inferred from direct assay	21196491	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	17804407	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

retinoschisin

X-linked juvenile retinoschisis protein homolog

retinoschisis 1 homolog

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-19793	RS-1	Activator	99.77%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147558	CB1R Allosteric modulator 1	Modulator	/	Unkown
HY-147559	CB1R Allosteric modulator 2	Modulator	/	Unkown
HY-RS12295	RS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17092	Rs1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23536	Rs1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rs1	NCBI	NCBI:6247
Macaca fascicularis	Rs1	NCBI	NCBI:107128453
Rattus norvegicus	Rs1	NCBI	NCBI:100125595

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