Reg3g - regenerating islet-derived 3 gamma Gene

Mus musculus

Also known as REG-3-gamma; reg III-gamma

Gene ID: 19695 | Gene type: protein coding

About Reg3g

Summary

This gene encodes a C-type lectin that demonstrates bactericidal activity. This gene is predominantly expressed in the distal small intestine where the encoded protein undergoes proteolytic processing by trypsin. Mice lacking the encoded protein exhibit altered mucus distribution, increased Bacterial contact with the epithelium, and elevated inflammatory markers in the ileum, and low-grade inflammation. [provided by RefSeq, Jun 2016]

Reg3g Products(1)

mRNA	Protein	Name
NM_011260.2	NP_035390.1	regenerating islet-derived protein 3-gamma preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables hormone activity	IDA IDA: Inferred from direct assay	22727489	MGI
enables hormone activity	IMP IMP: Inferred from mutant phenotype	36240758	MGI
enables oligosaccharide binding	IDA IDA: Inferred from direct assay	16931762	MGI
enables peptidoglycan binding	IDA IDA: Inferred from direct assay	16931762	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in MyD88-dependent toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17635956	MGI
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	16931762	MGI
involved in defense response to Gram-negative bacterium	IDA IDA: Inferred from direct assay	16931762	MGI
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	16931762	MGI
involved in defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	17635956	MGI
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	28811323	MGI
involved in negative regulation of inflammatory response to wounding	IDA IDA: Inferred from direct assay	27830702	MGI
involved in negative regulation of keratinocyte differentiation	IDA IDA: Inferred from direct assay	22727489	MGI
involved in positive regulation of detection of glucose	IMP IMP: Inferred from mutant phenotype	36240758	MGI
involved in positive regulation of keratinocyte proliferation	IDA IDA: Inferred from direct assay	22727489	MGI
involved in positive regulation of wound healing	IDA IDA: Inferred from direct assay	22727489	MGI
acts upstream of or within response to bacterium	IEP IEP: Inferred from expression pattern	23012479	MGI
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	35263589	MGI
involved in response to symbiotic bacterium	IDA IDA: Inferred from direct assay	36240758	MGI
involved in response to wounding	IDA IDA: Inferred from direct assay	22727489	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with extracellular space	IDA IDA: Inferred from direct assay	16931762	MGI
is active in extracellular space	IDA IDA: Inferred from direct assay	22727489	MGI
located in secretory granule	IDA IDA: Inferred from direct assay	16931762	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

regenerating islet-derived protein 3-gamma

generating islet-derived, mouse homolog 3 gamma	pancreatitis-associated protein 3
regenerating islet-derived protein III-gamma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11821	REG3G Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19737	Reg3g Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26233	Reg3g Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Reg3g	NCBI	NCBI:130120

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